FYN
FYN全称为酪氨酸蛋白激酶Fyn,属于Src家族成员,在细胞信号传导中发挥核心作用。FYN存在两种异构体,分别通过不同剪切方式产生p59-Fyn和p58-Fyn,在T细胞受体激活、神经元发育等过程中参与调控。其异常活化与多种恶性肿瘤密切相关,Fyn激酶在乳腺癌、前列腺癌中通过PI3K/AKT通路促进肿瘤转移,在胶质母细胞瘤中与表皮生长因子受体形成致癌复合物。阿尔茨海默病患者脑组织中发现Fyn与Tau蛋白异常互作,加速神经纤维缠结形成,而帕金森病模型中也观察到该激酶对α-突触核蛋白聚集的促进作用。针对Fyn的药物开发聚焦于激酶抑制剂领域,达沙替尼等广谱Src抑制剂已进入临床研究,新型选择性抑制剂如AZD0424在临床前实验中显示出对三阴性乳腺癌的特异性抑制作用。近期研究还发现Fyn在免疫检查点调控中的作用,其与PD-1受体的相互作用为肿瘤免疫治疗提供了新靶点。
热销产品
FYN Recombinant Monoclonal Antibody (CSB-RA699767A0HU)
验证数据

IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
FYN Antibodies
FYN for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA112548 | Phospho-FYN (Tyr530) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA914183 | FYN (Ab-530) Antibody | Human,Mouse | ELISA,WB |
CSB-PA002595 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA008519 | Phospho-FYN (Y530) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA008520 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA143385 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA225018 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA009101LA01HU | FYN Antibody | Human | ELISA, IHC, IF |
CSB-RA699767A0HU | FYN Recombinant Monoclonal Antibody | Human | ELISA, IHC |
FYN Proteins
FYN Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101MO CSB-EP009101MO CSB-BP009101MO CSB-MP009101MO CSB-EP009101MO-B |
Recombinant Mouse Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101HU CSB-EP009101HU CSB-BP009101HU CSB-MP009101HU CSB-EP009101HU-B |
Recombinant Human Tyrosine-protein kinase Fyn (FYN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Bos taurus (Bovine)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101BO CSB-EP009101BO CSB-BP009101BO CSB-MP009101BO CSB-EP009101BO-B |
Recombinant Bovine Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Sus scrofa (Pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101PI CSB-EP009101PI CSB-BP009101PI CSB-MP009101PI CSB-EP009101PI-B |
Recombinant Pig Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xenopus laevis (African clawed frog)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101XBE CSB-EP009101XBE CSB-BP009101XBE CSB-MP009101XBE CSB-EP009101XBE-B |
Recombinant Xenopus laevis Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xiphophorus helleri (Green swordtail)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009101XBJ CSB-EP009101XBJ CSB-BP009101XBJ CSB-MP009101XBJ CSB-EP009101XBJ-B |
Recombinant Xiphophorus helleri Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP723478RA CSB-EP723478RA CSB-BP723478RA CSB-MP723478RA CSB-EP723478RA-B |
Recombinant Rat Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |