Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit

    CCL2，全称为趋化因子C-C motif ligand 2，也称为单核细胞趋化蛋白1（MCP-1）。它是一种细胞因子，参与了许多生理和病理过程，如炎症、肿瘤、自身免疫性疾病等。CCL2主要由单核细胞、巨噬细胞和内皮细胞分泌，在炎症和组织损伤时被激活。CCL2可引导单核细胞、记忆性T细胞和树突状细胞等进入炎症和损伤组织，促进炎症反应和组织修复。CCL2也参与了肿瘤的发生和发展，可以引起肿瘤相关的炎症反应，增加肿瘤细胞的浸润和转移。

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. May play a significant role in monocyte trafficking into the reperfused myocardium.

1. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983 PMID: 29304171
2. data suggest that CCL2 acts as a PMNs chemotactic factor as well as CXCL8, and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of idiopathic polyarthritis PMID: 27863550
3. The study findings suggest that both CCL2 and CXCL8 are involved in the pathogenesis of canine idiopathic pulmonary fibrosis. PMID: 26231926
4. CCL2 concentrations might be related to the breed predisposition of the West Highland white terrier for canine idiopathic pulmonary fibrosis. PMID: 26267090
5. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs. PMID: 22986270
6. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10. PMID: 18717642

显示更多

收起更多

Secreted.

Intercrine beta (chemokine CC) family

Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.

KEGG: cfa:403981

STRING: 9615.ENSCAFP00000027107

UniGene: Cfa.3851