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  4. Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit

Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit

文献引用 (1) 说明书下载
  • 中文名称：
    人癌胚抗原相关细胞粘附分子8(CEACAM8)酶联免疫试剂盒
  • 货号：
    CSB-EL005168HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    人癌胚抗原相关细胞粘附分子8(CEACAM8)酶联免疫试剂盒（CSB-EL005168HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆、细胞裂解物样本中的CEACAM8含量。CEACAM8，也称为CD66b，是免疫球蛋白超家族的一员，主要在粒细胞中表达。它通过调节细胞间粘附和信号传导参与免疫反应，尤其在肿瘤微环境中发挥重要作用。CEACAM8的研究机制涉及其在肿瘤中的调节机制、免疫信号机制以及与多种疾病如乳腺癌、宫颈癌和膀胱癌的关系。试剂盒检测范围为0.625 ng/mL-40 ng/mL，适用于体外检测多种生物样本中CEACAM8的表达水平，可为研究中性粒细胞介导的免疫反应机制、炎症相关疾病模型建立及肿瘤微环境调控等基础科研领域提供可靠工具，其定量数据亦可作为探索CEACAM8作为炎症或肿瘤相关生物标志物的研究依据。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    Carcinoembryonic antigen CGM6 ELISA Kit; Carcinoembryonic antigen gene family member 6 ELISA Kit; Carcinoembryonic antigen related cell adhesion molecule 8 ELISA Kit; Carcinoembryonic antigen-related cell adhesion molecule 8 ELISA Kit; CD 66b ELISA Kit; CD 67 ELISA Kit; CD66b ELISA Kit; CD66b antigen ELISA Kit; CD67 ELISA Kit; CD67 antigen ELISA Kit; CEACAM 8 ELISA Kit; CEACAM8 ELISA Kit; CEAM8_HUMAN ELISA Kit; CGM 6 ELISA Kit; CGM6 ELISA Kit; NCA 95 ELISA Kit; NCA95 ELISA Kit; Non-specific cross-reacting antigen NCA-95 ELISA Kit; Nonspecific cross reacting antigen NCA 95 ELISA Kit; Nonspecific cross reacting antigen NCA95 ELISA Kit
  • 缩写：
    CEACAM8
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    0.625 ng/mL-40 ng/mL
  • 灵敏度：
    0.156 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CEACAM8 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %85-96
    1:2Average %96
    Range %92-103
    1:4Average %102
    Range %95-108
    1:8Average %88
    Range %86-91
  • 回收率：
    The recovery of human CEACAM8 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9186-95
    EDTA plasma (n=4)9794-101
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    402.322 2.525 2.424 2.273
    201.989 1.966 1.978 1.827
    101.365 1.481 1.423 1.272
    50.975 1.052 1.014 0.863
    2.50.603 0.625 0.614 0.463
    1.250.369 0.347 0.358 0.207
    0.6250.272 0.280 0.276 0.125
    00.146 0.155 0.151
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

引用文献

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相关产品

CEACAM8 antibodies

CEACAM8 Proteins

靶点详情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能参考文献：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 组织特异性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 数据库链接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41

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