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  4. Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit

Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit

文献引用 (1) 说明书下载
  • 中文名称：
    人补体C1q肿瘤坏死因子相关蛋白1(C1QTNF1/CTRP1)酶联免疫试剂盒
  • 货号：
    CSB-E16713h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    CUSABIO人补体C1q肿瘤坏死因子相关蛋白1（C1QTNF1/CTRP1）酶联免疫检测试剂盒（货号：CSB-E16713h），基于双抗体夹心法原理设计，可对血清、血浆及组织匀浆样本中的CTRP1蛋白进行定量分析，灵敏度可达0.312 ng/mL，线性范围延伸至20 ng/mL。CTRP1属于补体C1q/肿瘤坏死因子超家族成员，在代谢调节、炎症反应及细胞分化中发挥重要作用，其表达水平与肥胖、糖尿病及心血管疾病等病理机制相关。该试剂盒通过特异性抗体对实现靶标的高效捕获与检测，适用于基础科研中探索CTRP1在代谢性疾病模型中的功能调控、炎症信号通路研究，或作为生物标志物在动物实验及细胞实验中的定量分析工具，为揭示其在能量代谢、脂肪组织功能及慢性疾病发生发展中的作用提供可靠检测方案。试剂盒包含预包被微孔板、标准品、检测抗体及显色系统等完整组分，操作流程标准化，可满足实验室对微量样本的高通量检测需求。
  • 别名：
    C1q and tumor necrosis factor related protein 1 ELISA Kit; C1QT1_HUMAN ELISA Kit; C1QTNF1 ELISA Kit; Complement C1q tumor necrosis factor related protein 1 ELISA Kit; Complement C1q tumor necrosis factor-related protein 1 ELISA Kit; CTRP 1 ELISA Kit; CTRP1 ELISA Kit; FLJ90694 ELISA Kit; G protein coupled receptor interacting protein 1 ELISA Kit; G protein-coupled receptor-interacting protein ELISA Kit; GIP ELISA Kit; ZSIG37 ELISA Kit
  • 缩写：
    C1QTNF1
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.312 ng/mL-20 ng/mL
  • 灵敏度：
    0.078 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CTRP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 98
    Range % 94-102
    1:2 Average % 102
    Range % 97-107
    1:4 Average % 91
    Range % 87-95
    1:8 Average % 104
    Range % 97-108
  • 回收率：
    The recovery of human CTRP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 91 87-95
    EDTA plasma (n=4) 103 98-107
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.274 2.312 2.293 2.190
    10 1.258 1.354 1.306 1.203
    5 0.698 0.735 0.717 0.614
    2.5 0.430 0.447 0.439 0.336
    1.25 0.275 0.288 0.282 0.179
    0.625 0.174 0.184 0.179 0.076
    0.312 0.139 0.147 0.143 0.040
    0 0.102 0.103 0.103 　
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

引用文献

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C1QTNF1 antibodies

C1QTNF1 Proteins

靶点详情

  • 基因功能参考文献：
    1. CTRP1 has a role in linking dysregulation of lipid metabolism and inflammatory responses in macrophages PMID: 27175610
    2. High serum CTRP1 level is associated with Type 2 diabetes mellitus. PMID: 28207876
    3. In cultured endothelial cells, treatment of CTRP1 led to increased permeability to fluorescent-labelled dextran and apparent formation of paracellular holes as observed after disturbed flow exposure, which was evidently reduced in the presence of a CTRP1-specific neutralizing antibody. PMID: 28625919
    4. Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction. PMID: 27169633
    5. the strong association of CTRP1 with insulin resistance in NAFLD PMID: 25767880
    6. The levels of circulating CTRP1 are associated with coronary artery disease in men. PMID: 24945145
    7. The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. PMID: 25635749
    8. Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state. PMID: 24965225
    9. CTRP1 is a novel adipokine associated with type 2 diabetes mellitus in humans. PMID: 24827430
    10. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. PMID: 23000311
    11. The review describes the potential role of C1qTNF1 as an intracellular regulator of signal transduction PMID: 16386877
    12. molecular cloning, gene expression, and subcellular localization of GIP PMID: 12409230
    13. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. PMID: 16806199
    14. CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. PMID: 18171693
    15. CTRP1 may be considered a novel adipokine, providing an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. PMID: 18783346

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 14324

    OMIM: 610365

    KEGG: hsa:114897

    STRING: 9606.ENSP00000340864

    UniGene: Hs.201398

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