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  4. Human Dickkopf-related protein 4(DKK4) ELISA kit

Human Dickkopf-related protein 4(DKK4) ELISA kit

说明书下载
  • 中文名称：
    人Dickkopf相关蛋白4(DKK4)酶联免疫试剂盒
  • 货号：
    CSB-EL006923HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    人Dickkopf相关蛋白4(DKK4)酶联免疫试剂盒（CSB-EL006923HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆、细胞裂解物样本中的DKK4含量。DKK4是一种重要靶点。它在胚胎发育、组织稳态维持等方面有一定作用。研究发现，其异常表达与肿瘤发生发展等病理过程相关，可能通过参与Wnt信号通路等机制发挥影响，对它的深入研究有望为相关疾病治疗提供新策略。试剂盒检测范围为0.625 ng/mL-40 ng/mL，本试剂盒适用于体外实验环境下的基础科研，如癌症生物学模型验证、信号通路互作研究或疾病生物标志物探索，支持多类型样本的同步检测以满足不同实验设计需求，助力研究者深入解析DKK4在疾病调控网络中的功能及潜在干预靶点。适用于血清、血浆、组织匀浆及细胞裂解液样本中DKK4蛋白的精准分析，可用于研究DKK4在肿瘤发生、干细胞分化或组织再生中的作用。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    Dickkopf 4 ELISA Kit; Dickkopf gene 4 ELISA Kit; Dickkopf homolog 4 (Xenopus laevis) ELISA Kit; Dickkopf homolog 4 ELISA Kit; Dickkopf related protein 4 ELISA Kit; Dickkopf-4 ELISA Kit; Dickkopf-related protein 4 short form ELISA Kit; Dickkopf4 ELISA Kit; DKK 4 ELISA Kit; Dkk-4 ELISA Kit; DKK4 ELISA Kit; DKK4_HUMAN ELISA Kit; hDkk 4 ELISA Kit; hDkk-4 ELISA Kit; hDkk4 ELISA Kit; MGC129562 ELISA Kit; MGC129563 ELISA Kit
  • 缩写：
    DKK4
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    0.625 ng/mL-40 ng/mL
  • 灵敏度：
    0.156 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Stem Cells
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

产品评价

相关产品

DKK4 antibodies

DKK4 Proteins

靶点详情

  • 功能：
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 基因功能参考文献：
    1. Data suggest a critical role of dickkopf 4 (DKK4) in docetaxel resistance of the lung adenocarcinoma A549 (A549/DTX) cells. PMID: 28981599
    2. in NOD/SCID mice supplemented with high glucose, HepG2 xenografted tumors grew rapidly in which elevated levels of beta-catenin, c-Myc and decreased levels of DKK4 were detected. Knockdown of DKK4 by shRNA promotes proliferation of HCC cells in NG, which is suppressed by treating cells exogenously with recombinant DKK4 protein. Our in vitro and in vivo results indicate an important functional role of DKK4 in glucose fa... PMID: 27272409
    3. Our results indicated that DKK4 might be contributed to predicting EOC progression and prognosis. DKK4 could promote the invasion of EOC through JNK activation. PMID: 28666421
    4. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. PMID: 28450117
    5. DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. DKK4 may have function on the development and progression of pancreatic cancer. PMID: 26880586
    7. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
    8. DKK4 upregulated by T3/TR antagonizes the Wnt signal pathway to suppress tumor cell progression PMID: 23958302
    9. rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively. PMID: 23516639
    10. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations. PMID: 23108157
    11. Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC. PMID: 22249261
    12. Found the unique expression of the Wnt antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy. PMID: 22740476
    13. The TR/DKK4/Wnt/beta-catenin cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor. PMID: 21994129
    14. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. Functional assays confirm that TFAP2E-dependent resistance is mediated through DKK4. PMID: 22216841
    15. Polymorphism of DKK4 was significantly associated with brain volume in Chinese individuals. PMID: 21341386
    16. chromosome 8 mapping by FISH PMID: 11701963
    17. DKK4 may play a role in schizophrenia pathogenesis PMID: 17553464
    18. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis. PMID: 18408752
    19. DKK4 is an important negative regulator of colon cancer cell growth. PMID: 19059704
    20. Dickkopf-4 and -2 are significantly upregulated in most colorectal tumors PMID: 19659606

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Dickkopf family
  • 组织特异性：
    Expressed in cerebellum, T-cells, esophagus and lung.
  • 数据库链接：

    HGNC: 2894

    OMIM: 605417

    KEGG: hsa:27121

    STRING: 9606.ENSP00000220812

    UniGene: Hs.159311

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