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  4. Human Fibroblast growth factor 20(FGF20) ELISA kit

Human Fibroblast growth factor 20(FGF20) ELISA kit

文献引用 (2) 说明书下载
  • 中文名称：
    人成纤维细胞生长因子20(FGF20)酶联免疫试剂盒
  • 货号：
    CSB-EL008626HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    CUSABIO人成纤维细胞生长因子20（FGF20）酶联免疫试剂盒（货号：CSB-EL008626HU），采用双抗体夹心法定量检测血清、血浆、组织匀浆及细胞裂解液样本中的FGF20蛋白浓度，检测灵敏度为12.5 pg/mL，线性范围为12.5-800 pg/mL。FGF20是成纤维细胞生长因子家族成员，参与神经发育调控、组织修复再生等生物学过程，其异常表达与帕金森病、毛囊发育障碍等疾病相关。本试剂盒包含预包被捕获抗体的96孔板、检测抗体、标准品、显色试剂及终止液，通过两次37℃孵育（首次60分钟，二次30分钟）完成抗原抗体反应，适用于基础科研中FGF20蛋白表达水平的定量分析，例如研究神经系统疾病模型中的分子机制、评估组织再生相关通路活性，或探索药物干预对FGF20表达的影响。检测样本需离心去除颗粒物，血浆建议使用EDTA或肝素抗凝管收集，组织样本需制备为10%浓度匀浆液后进行检测。试剂在2-8℃保存有效期为6个月，避免反复冻融。
  • 别名：
    FGF-20 ELISA Kit; Fgf20 ELISA Kit; FGF20_HUMAN ELISA Kit; FGFK ELISA Kit; Fibroblast growth factor 20 ELISA Kit; RHDA2 ELISA Kit
  • 缩写：
    FGF20
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    12.5 pg/mL-800 pg/mL
  • 灵敏度：
    3.12 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

引用文献

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FGF20 antibodies

FGF20 Proteins

靶点详情

  • 功能：
    Neurotrophic factor that regulates central nervous development and function.
  • 基因功能参考文献：
    1. Studied effect of recombinant human fibroblast growth factor 20 (rhFGF20) on cultured mouse vibrissal follicles; found rhFGF20 significantly induced growth of the follicles in vitro, stimulated proliferation of hair matrix cells, and activated Wnt signal pathway. PMID: 29713847
    2. This study confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0.013). Additionally, subjects with the AA + AG genotype have a reduced risk compared to individuals with the GG genotype (P = 0.024). PMID: 28238162
    3. the FGF20 gene might not play a dominating role in the genetic predisposition to essential tremor in Chinese Han population. PMID: 27040428
    4. Meta-analysis indicated that the rs12720208 polymorphism may be associated with the Parkinson's disease susceptibility in Caucasians PMID: 28191856
    5. This study suggested that there is no sufficient evidence to support the association between FGF20 rs12720208 polymorphism and Parkinson's disease risk. PMID: 27023076
    6. The results of this study indicated that rs12720208 may contribute to the risk of PD in Iranian population. PMID: 26070653
    7. Meta-analysis suggests that FGF20 rs1721100 C/G polymorphism is associated with sporadic sporadic Parkinson's diseases in Asians PMID: 25030126
    8. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model. PMID: 24942208
    9. The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between Parkinson's disease patients and controls. PMID: 23938014
    10. The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia PMID: 23516905
    11. This study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with Parkinson's disease. PMID: 22342445
    12. The data suggested that Fgf9/20 and Bmp7 organize the nephron progenitor niche and highlight the essential role of FGF20 in human kidney development. FGF signaling likely regulates multiple important steps in the stem cell niche. PMID: 22698282
    13. The common FGF20 rs12720208 SNP was not associated with the risk for Parkinson's disease (PD) in our population. In addition, we did not find nucleotide changes in miR-433 (that binds to the 3' UTR FGF20 mRNA) among our PD patients. PMID: 20471450
    14. The associations described, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging. PMID: 20427658
    15. Fibroblast growth factor 20 polymorphisms and haplotypes is associated with the risk of Parkinson disease PMID: 15122513
    16. Data show that FGF20 and DKK1 appear to be direct targets for beta-catenin/TCF transcriptional regulation via LEF/TCF-binding sites, and are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway PMID: 15592430
    17. results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population PMID: 17515805
    18. Variants in FGF20 and MAOB show evidence of statistical interactions and potential patterns of biological interaction contributing to Parkinson disease risk. PMID: 18205889
    19. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. PMID: 18252210
    20. FGF20 is associated with Parkinson's disease synergistically with SNCA. PMID: 18568448
    21. Data demonstrate that homodimerization autoregulates FGF9 and FGF20's receptor binding and concentration gradients in the extracellular matrix. PMID: 19564416
    22. The effect of arginine on the solubility and stability of FGF-20 was dominated by the preferential binding interaction. PMID: 19619121
    23. FGF20, FGF9, and FGF16 constitute a subfamily among FGFs. FGF20 is preferentially expressed in colorectal cancer. PMID: 10913340

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  • 相关疾病：
    Renal hypodysplasia/aplasia 2 (RHDA2)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Predominantly expressed in the cerebellum.
  • 数据库链接：

    HGNC: 3677

    OMIM: 605558

    KEGG: hsa:26281

    STRING: 9606.ENSP00000180166

    UniGene: Hs.199905

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