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  4. Human monocyte chemotactic protein 4,MCP-4 ELISA kit

Human monocyte chemotactic protein 4,MCP-4 ELISA kit

说明书下载
  • 中文名称：
    人单核细胞趋化蛋白4(MCP-4/CCL13)酶联免疫试剂盒
  • 货号：
    CSB-E09762h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    人单核细胞趋化蛋白4(MCP-4/CCL13)酶联免疫试剂盒（CSB-E09762h）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆.样本中的CCL13含量。CCL13是一个值得关注的靶点。它属于趋化因子家族，在炎症反应、免疫调节等生理过程中发挥作用。研究聚焦于其与疾病发生发展机制的关联，如在某些炎症性疾病、肿瘤中，CCL13可能参与细胞迁移、侵袭等，有望成为治疗干预靶点。试剂盒检测范围为39 pg/ml-2500 pg/ml.，灵敏度为9.75 pg/ml.。产品适用于体外研究领域，包括炎症机制探索、疾病模型建立、药物干预效果评估等基础科研场景，例如通过检测不同实验条件下生物样本中MCP - 4/CCL13的动态变化，揭示其在免疫调节网络中的作用机制。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    C-C motif chemokine 13 ELISA Kit; CCL13 ELISA Kit; CCL13_HUMAN ELISA Kit; Chemokine (C C motif) ligand 13 ELISA Kit; CK beta 10 ELISA Kit; CK-beta-10 ELISA Kit; CKb10 ELISA Kit; MCP-4 ELISA Kit; MGC17134 ELISA Kit; Monocyte chemoattractant protein 4 ELISA Kit; Monocyte chemotactic protein 4 ELISA Kit; NCC 1 ELISA Kit; NCC-1 ELISA Kit; NCC1 ELISA Kit; New CC chemokine 1 ELISA Kit; SCYA13 ELISA Kit; SCYL1 ELISA Kit; short chain ELISA Kit; Small inducible cytokine A13 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 13 ELISA Kit; Small-inducible cytokine A13 ELISA Kit
  • 缩写：
    CCL13
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates.
  • 检测范围：
    39 pg/ml-2500 pg/ml.
  • 灵敏度：
    9.75 pg/ml.
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

产品评价

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CCL13 antibodies

CCL13 Proteins

靶点详情

  • 功能：
    Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
  • 基因功能参考文献：
    1. CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis. PMID: 25654294
    3. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
    4. Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW] PMID: 23846739
    5. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. PMID: 23375121
    6. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha-induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA. PMID: 22393877
    7. Findings suggest that the pro-atherogenic effects of CCR2 may not be restricted to interaction with MCP-1, but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation. PMID: 20139115
    8. Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene. PMID: 12805085
    9. The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. PMID: 14560935
    10. MCP-4 may be a critical molecule that links obesity and chronic inflammation. PMID: 16855189
    11. The Th2 cytokine IL-4 preferentially stimulated MCP-4 expression. PMID: 17541284
    12. interferon-gamma with IL-1beta/TNF-alpha activates the production of CCL13 from chondrocytes in RA joints; secreted CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated MAP kinases cascade PMID: 17824960
    13. TLR2, 3, 4 and 5 ligands, but not TLR7/8 or 9 ligands, synergized with IL-4 to induce the production of MCP-4 in nasal polyp fibroblasts. PMID: 17851891
    14. CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase. PMID: 18219197
    15. Oncostatin M can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with rheumatoid arthritis. PMID: 19565514

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
  • 数据库链接：

    HGNC: 10611

    OMIM: 601391

    KEGG: hsa:6357

    STRING: 9606.ENSP00000225844

    UniGene: Hs.414629

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