Monkey monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit

产品详情

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Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

产品描述：

猴子单核细胞趋化蛋白1(MCP-1/CCL2/MCAF)酶联免疫试剂盒（CSB-E10045Mo）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的CCL2含量。CCL2 是一种趋化因子，广泛参与炎症反应、免疫调节等生理病理过程。其背景在于在多种疾病如肿瘤、炎症性疾病中高表达。研究机制方面，它主要通过与受体结合，招募巨噬细胞等免疫细胞，在疾病发生发展进程中发挥重要作用。试剂盒检测范围为62.5 pg/mL-4000 pg/mL，适用于灵长类动物模型研究中MCP - 1表达水平的动态监测，例如炎症性疾病机制探索、免疫治疗药物效果评估或肿瘤微环境相关研究，为体外实验中蛋白定量分析提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

CCL2 ELISA kit; MCP1 ELISA kit; SCYA2C-C motif chemokine 2 ELISA kit; Monocyte chemoattractant protein 1 ELISA kit; Monocyte chemotactic protein 1 ELISA kit; MCP-1 ELISA kit; Small-inducible cytokine A2 ELISA kit
缩写：

CCL2
Uniprot No.：

P61275
种属：

Monkey
样本类型：

serum, plasma, tissue homogenates
检测范围：

62.5 pg/mL-4000 pg/mL
灵敏度：

15.6 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Immunology
测定原理：

quantitative
测定方法：

Sandwich

精密度：

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
亚细胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
数据库链接：

KEGG: mcc:574138

STRING: 9544.ENSMMUP00000000391

UniGene: Mmu.3491