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  4. Mouse C-X-C motif chemokine 11(CXCL11) ELISA kit

Mouse C-X-C motif chemokine 11(CXCL11) ELISA kit

文献引用 (1) 说明书下载
  • 中文名称：
    小鼠C-X-C趋化因子11(CXCL11)酶联免疫试剂盒
  • 货号：
    CSB-EL006241MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
    CUSABIO试剂盒采用双抗体夹心酶联免疫法，专为定量检测小鼠血清、血浆、细胞培养上清及组织匀浆中的C-X-C趋化因子11（CXCL11）设计。CXCL11作为趋化因子家族成员，在免疫细胞趋化、炎症反应及自身免疫疾病调控中发挥重要作用。试剂盒检测范围为31.25-2000 pg/mL，可精确测定样本中低至31.25 pg/mL的CXCL11蛋白浓度，适用于基础科研中炎症机制研究、免疫调节实验或药物开发模型的生物标志物分析。通过预包被特异性捕获抗体与标记检测抗体的协同作用，确保实验的高特异性与重复性，支持多种样本类型的灵活选择：血清/血浆适用于体内病理模型分析，细胞培养上清可用于体外细胞因子分泌研究，而组织匀浆则满足组织特异性表达检测需求。CUSABIO科研人员探索CXCL11在感染性疾病、肿瘤微环境及免疫相关疾病中的功能提供了可靠工具，适用于分子生物学、免疫学等领域的基础研究。
  • 别名：
    Cxcl11 ELISA Kit; Scyb11C-X-C motif chemokine 11 ELISA Kit; Interferon-inducible T-cell alpha chemoattractant ELISA Kit; I-TAC ELISA Kit; Small-inducible cytokine B11 ELISA Kit
  • 缩写：
    CXCL11
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, cell culture supernates,tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

引用文献

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Cxcl11 antibodies

Cxcl11 Proteins

靶点详情

  • 功能：
    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
  • 基因功能参考文献：
    1. although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
    2. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
    3. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
    4. Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
    5. Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
    6. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
    7. the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
    8. I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
    9. I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
    10. Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
    11. homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 数据库链接：

    KEGG: mmu:56066

    UniGene: Mm.131723

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