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中文名称:小鼠C-X-C趋化因子11(CXCL11)酶联免疫试剂盒
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货号:CSB-EL006241MO
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:CUSABIO试剂盒采用双抗体夹心酶联免疫法,专为定量检测小鼠血清、血浆、细胞培养上清及组织匀浆中的C-X-C趋化因子11(CXCL11)设计。CXCL11作为趋化因子家族成员,在免疫细胞趋化、炎症反应及自身免疫疾病调控中发挥重要作用。试剂盒检测范围为31.25-2000 pg/mL,可精确测定样本中低至31.25 pg/mL的CXCL11蛋白浓度,适用于基础科研中炎症机制研究、免疫调节实验或药物开发模型的生物标志物分析。通过预包被特异性捕获抗体与标记检测抗体的协同作用,确保实验的高特异性与重复性,支持多种样本类型的灵活选择:血清/血浆适用于体内病理模型分析,细胞培养上清可用于体外细胞因子分泌研究,而组织匀浆则满足组织特异性表达检测需求。CUSABIO科研人员探索CXCL11在感染性疾病、肿瘤微环境及免疫相关疾病中的功能提供了可靠工具,适用于分子生物学、免疫学等领域的基础研究。
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别名:Cxcl11 ELISA Kit; Scyb11C-X-C motif chemokine 11 ELISA Kit; Interferon-inducible T-cell alpha chemoattractant ELISA Kit; I-TAC ELISA Kit; Small-inducible cytokine B11 ELISA Kit
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缩写:
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Uniprot No.:
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种属:Mus musculus (Mouse)
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样本类型:serum, plasma, cell culture supernates,tissue homogenates
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检测范围:31.25 pg/mL-2000 pg/mL
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灵敏度:7.81 pg/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Immunology
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
引用文献
相关产品
靶点详情
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功能:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
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基因功能参考文献:
- although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
- These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
- very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
- Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
- Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
- Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
- the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
- I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
- I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
- Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
- homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837
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亚细胞定位:Secreted.
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蛋白家族:Intercrine alpha (chemokine CxC) family
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数据库链接: