Mouse Insulin-like growth factor binding protein 3,IGFBP-3 ELISA KIT

IGFBP3是一种结合胰岛素样生长因子1（IGF1）的蛋白质，它在调节细胞增殖、凋亡和分化等多种生物学过程中起重要作用。最新的研究显示，IGFBP3在多种肿瘤中具有潜在的抗肿瘤作用，其具体机制可能涉及调节细胞周期、促进细胞凋亡和抑制肿瘤血管生成等方面。此外，IGFBP3还与多种代谢性疾病和心血管疾病的发病和预后有关，如2型糖尿病、高血压、冠心病等。

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.

1. Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells PMID: 28330997
2. endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors. PMID: 27448965
3. High Igfbp3 expression is associated with skin squamous cell carcinoma. PMID: 28807942
4. The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt pathway and depends upon the presence of CD44, a receptor protein known to modulate Wnt signaling. PMID: 27377812
5. IGFBP-3 influences severity of DSS-induced colitis. PMID: 27253188
6. our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain PMID: 28088287
7. IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury. PMID: 26073647
8. An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage. PMID: 25082650
9. Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis. PMID: 25614235
10. Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC migration. PMID: 24358328
11. IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy. PMID: 22792172
12. IGFBP-3 activates inhibitory Smad signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta. PMID: 22910030
13. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. PMID: 22034491
14. IGFBP-3 positively and negatively impacts on IGF1-induced lung cancer development. PMID: 21447628
15. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
16. Mice genetically deficient in IGFBP-3 have weaker growth of primary prostate tumors but higher incidence of metastases. PMID: 21697285
17. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease. PMID: 21383009
18. IGFBP-3 has a role in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury PMID: 21435441
19. The authors showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in Borna disease virus P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice. PMID: 21325425
20. Association between Igfbp3 and risk of prostatic cancer are examined. PMID: 20473871
21. This study provides evidence that genetic deletion of IGFBP-3 modulates hepatic carbohydrate and lipid metabolism. PMID: 20926583
22. Data indicate that impairment of IGF-1 complex formation with insulin-like growth factor binding protein, acid labile subunit in bone marrow alters cell fate, leading to increased adipogenesis. PMID: 20007694
23. IGFBP3 and Humanin play key roles in the coordinated regulation of testicular germ cell homeostasis. PMID: 19952275
24. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa. PMID: 19777566
25. response to nutritional stsatus chanes in PPARalpha knockout mice PMID: 11735249
26. overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance. PMID: 12376320
27. IGFBP-3 increases osteoclast number and bone resorption, impairs osteoblast proliferation, and has a significant negative effect on bone formation PMID: 14584894
28. N- and C-terminal residues of IGFBP-3 have roles in regulating IGF complex formation and receptor activation PMID: 15485880
29. the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms PMID: 15550509
30. IGFBP-3 induces apoptosis through an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77 PMID: 15731112
31. Overexpression of Hbegf in transgenic mice downregulates Igfbp3. PMID: 16019424
32. Igfbp3 modulates cell proliferation in the hair follicle. PMID: 16185287
33. IGFBP-3 is upregulated by apigenin in a pathway leading to cancer growth inhibition and apoptosis PMID: 16230333
34. the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression PMID: 16469805
35. IGFBP-3 is a growth inhibitor molecule (news) PMID: 16617154
36. provide direct evidence for combinatorial effects of IGFBP-3, -4, and -5 in both metabolism and at least some soft tissues PMID: 16675541
37. IGFBP-3 has direct, IGF-independent inhibitory effects on angiogenesis providing an additional mechanism by which it exerts its tumor suppressive effects PMID: 16983336
38. IGFBP3 is a downstream gene regulated by MeCP2 and MeCP2 may contribute directly to the transcriptional expression of IGFBP3 in the brain. PMID: 17278996
39. In summary, the absence of the IGFBP-5 gene did not block the ability of IGF-I to stimulate intestinal growth, possibly because greater jejunal expression of IGFBP-3 compensates for the absence of IGFBP-5. PMID: 17332154
40. IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms PMID: 17388800
41. Igfbp3 regulates hematopoietic stem cell and endothelial precurosr cell function during vascular development. PMID: 17567755
42. Igfbp3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PMID: 17567756
43. SRC-3 maintains IGF-I in the circulation through enhancing VDR-regulated IGFBP-3 expression. PMID: 18212051
44. Data suggest that loss of expression of IGFBPs (IGFBP-3 and IGFBP-4) in tumor cells treated with EGFR tyrosine kinase inhibitors derepresses IGFIR signaling, which in turn mediates resistance to EGFR antagonists. PMID: 18568074
45. IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. PMID: 18924579
46. IGFBP-3 inhibits adipocyte differentiation. PMID: 19141684
47. IGFBP3 is a new regulator of hypocretin cell physiology that may be involved not only in the pathophysiology of narcolepsy, but also in the regulation of sleep in normal individuals, most notably during adolescence PMID: 19158946
48. IGFBP-3 binds to fibronectin cell binding domain. PMID: 19236847
49. These studies reveal multisite phosphorylation of IGFBP-3 that both positively and negatively regulate its apoptotic potential. PMID: 19556345
50. IGFBP-3 mediated chondrocyte apoptosis is regulated by Gli2 and p53 in the progression from benign to malignant cartilage tumors. PMID: 19647223

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Secreted.

KEGG: mmu:16009

STRING: 10090.ENSMUSP00000020702

UniGene: Mm.29254