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中文名称：小鼠白介素-22受体α-2亚基(IL22RA2)酶联免疫试剂盒
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货号：CSB-EL011637MO
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：小鼠白介素-22受体α-2亚基(IL22RA2)酶联免疫试剂盒（CSB-EL011637MO）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的IL22RA2含量。IL22RA2是一个靶点。它是白细胞介素 22 的受体亚基，在免疫调节等生理过程中可能发挥重要作用。相关研究或聚焦其与疾病发生发展关联机制，如免疫失衡、炎症反应等，探索以此为靶点开发治疗药物或干预手段。试剂盒检测范围为46.88 pg/mL-3000 pg/mL，可为科研人员探究IL22RA2在免疫调节机制、炎症性疾病模型或肿瘤发生发展中的动态变化提供可靠工具；适用于基础研究中对体液或组织样本的蛋白表达水平监测，为探索相关疾病的分子机制提供数据支持。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：Il22ra2Interleukin-22 receptor subunit alpha-2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; soluble 1 ELISA Kit; CRF2-S1 ELISA Kit; Interleukin-22-binding protein ELISA Kit; IL-22BP ELISA Kit; IL22BP ELISA Kit; ZcytoR16 ELISA Kit
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缩写：
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Uniprot No.：
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种属：Mus musculus (Mouse)
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样本类型：serum, plasma, tissue homogenates
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检测范围：46.88 pg/mL-3000 pg/mL
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灵敏度：11.7 pg/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Immunology
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测定原理：quantitative
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测定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
线性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 94 Range % 90-97 1:2 Average % 100 Range % 95-103 1:4 Average % 95 Range % 89-100 1:8 Average % 89 Range % 84-92 -
回收率：
The recovery of mouse IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 90-97 EDTA plasma (n=4) 95 91-98 -
标准曲线：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 3000 2.412 2.423 2.418 2.258 1500 1.812 1.776 1.794 1.634 750 1.116 1.078 1.097 0.937 375 0.705 0.688 0.697 0.537 187.5 0.434 0.459 0.447 0.287 93.75 0.322 0.314 0.318 0.158 46.88 0.256 0.243 0.250 0.090 0 0.162 0.158 0.160 -
数据处理：
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货期：3-5 working days
引用文献
- Delivery of interleukin-22 binding protein (IL-22BP) gene by cationic micelle for colon cancer gene therapy Ke Men.et al,The Royal Society of Chemistry,2018
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靶点详情
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功能：Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
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基因功能参考文献：
- limits the pathological manifestations in models of allergic contact dermatitis and psoriasis PMID: 27676439
- Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression. PMID: 29109123
- IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function. PMID: 28512157
- IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS. PMID: 25008863
- the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon PMID: 23075849
- cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes PMID: 12700595
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亚细胞定位：Secreted.
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蛋白家族：Type II cytokine receptor family
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组织特异性：Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
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数据库链接：
