Mouse Thioredoxin-interacting protein(TXNIP) ELISA kit

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

1. TXNIP facilitates the oxidative stress response in glomerular mesangial cells partially through AMPK pathway. PMID: 30142540
2. Thioredoxin-interacting protein (Txnip) is highly induced in retinal vascular endothelial cells under diabetic conditions. Data (including data from studies using knockout mice) suggest that Txnip in retinal vascular endothelial cells plays role in diabetic retinal angiogenesis via Vegf/Vegfr2 and Akt/mTOR signaling. (Vegfr2 = vascular endothelial growth factor receptor-2) PMID: 29203232
3. These results suggest that mitochondrial ROS-TXNIP/NLRP3/IL-1beta axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction PMID: 29475133
4. crucial role in haematopoietic stem cell aging by inhibiting p38 activity via direct interaction PMID: 27929088
5. Data show that p38MAPK phosphorylation significantly increased in lentivirus vector thioredoxin interacting protein (LV-GFP-TXNIP) cells. PMID: 29169415
6. NLR family, pyrin domain containing 3 protein (NLRP3)-/- mice exhibited less severe non-alcoholic steatohepatitis (NASH) than WT mice, whereas thioredoxin-interacting protein (TXNIP) deficiency enhanced NLRP3 inflammasome. PMID: 28499273
7. TXNIP is a direct substrate of protein kinase B (AKT) and is responsible for mediating AKT-dependent acute glucose influx after growth factor stimulation. PMID: 28591573
8. Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS-TXNIP-NLRP3 axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D. PMID: 29278702
9. Here the authors demonstrate that thioredoxin-interacting protein (Txnip), which regulates glucose homeostasis in mammals, binds to fructose transporters and promotes fructose absorption by the small intestine. PMID: 27725089
10. thioredoxin-interacting protein deficiency alleviates diabetic renal lipid accumulation through regulation of Akt/mTOR pathway PMID: 27497988
11. All-trans retinoic acid plays a key role in inhibition of hepatic stellate cell activation via suppressing TXNIP expression, which reduces oxidative stress levels. PMID: 28322443
12. TXNIP-NFYA-SREBP2/miR-33a-AMPKalpha/CROT/CPT1/HADHB pathway is conserved in mouse, rat, and human cardiomyocytes and regulates myocardial beta-oxidation. PMID: 27199118
13. results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 inflammasome pathway. PMID: 28099758
14. proteomic and functional analyses demonstrated that Txnip inhibits glucose transport through direct binding to glucose transporter 1 (GLUT1). An ex vivo analysis of perfused hearts further demonstrated that the enhanced functional reserve afforded by deletion of Txnip was associated with myocardial glucose utilization during beta-adrenergic stimulation. PMID: 27037370
15. Thrombin activates reactive oxygen species (ROS)/thioredoxin binding protein (TXNIP)/NLRP3 signaling in BV2 microglia cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of intracerebral hemorrhage (ICH). PMID: 28202418
16. TxNIP appears to be an important factor in FFA-induced ROS generation and insulin resistance in skeletal muscle cells PMID: 27702549
17. Glucose exerts strong stimulatory effects on activation histone marks while having inhibitory effects on repression marks in the promoter of the TXNIP gene, and this was associated with a marked increase in expression of the proinflammatory gene in kidney. PMID: 26806835
18. Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS. PMID: 27131835
19. ITCH targets TXNIP for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin system. PMID: 26796253
20. Txnip plays an important role in oxidative inflammatory response and atherosclerotic lesion development in ApoE knockout mice. PMID: 26062991
21. The results indicate that a lack of TxNIP protects against diabetic nephropathy (DN) and support in vitro data that upregulation of TxNIP by glucose is a key mediator of early oxidative stress and a trigger for the development and progression of DN. PMID: 25855771
22. Reactive oxygen species regulation through REDD1/TXNIP is physiological rheostat controlling stress-induced autophagy. PMID: 25916556
23. These findings suggest that TXNIP is required for endothelial cell survival and homeostasis especially under stress conditions including hyperoxia. PMID: 25329456
24. HG-induced NADPH oxidase activation is driven by TXNIP which subsequently triggers NALP3 inflammasome activation in podocytes and ultimately led to podocyte injury PMID: 25834832
25. Data indicate that thioredoxin-interacting protein (TXNIP)levels are induced in erythroid differentiation. PMID: 25600403
26. In vivo, levels of lipogenic proteins, inflammatory molecules, PGC-1alpha, and PRMT1 were increased in the livers of HFD mice compared with those fed a chow diet, and were ameliorated in HFD Txnip(-/-) mice. PMID: 25003952
27. we demonstrated that TXNIP-mediated NLRP3 inflammasome activation in cardiac microvascular endothelial cells was a novel mechanism of myocardial ischemia/reperfusion injury PMID: 25015733
28. Genetic deletion of Txnip in cells and mice led to increased protein ubiquitination and splicing of the unfolded protein response regulated transcription factor X-box-binding protein 1 at baseline as well as under endoplasmic reticulum stress. PMID: 24843047
29. results demonstrate that TXNIP binding to NLRP3 is a key signaling mechanism necessary for hHcys-induced NLRP3 inflammasome formation and activation and subsequent glomerular injury. PMID: 25138219
30. TXNIP is a promising new target for the development of new therapies for the treatment of retinal neurodegenerative diseases. PMID: 24283717
31. The TXNIP expression is required for VEGF-mediated VEGFR2 activation and angiogenic response in vivo and in vitro. TXNIP expression regulates VEGFR-2 phosphorylation via S-glutathionylation of LMW-PTP in endothelial cells. PMID: 23718729
32. We demonstrated that TXNIP impairs glucose and insulin tolerance in mice by upregulating G6pc through interaction with small heterodimer partner (SHP). PMID: 24037087
33. studies have identified a novel TXNIP/miR-124a/FoxA2/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP and IAPP PMID: 24627476
34. Data suggest that in vitro fertilization and embryo culture, even under optimal conditions, lead to long-term metabolic alterations; up-regulation of Txnip in offspring may serve as a biological markers for these ill effects. PMID: 24684304
35. TXNIP regulates Src activation via regulation of VE-cadherin-SHP2-Src complex, resulting in altered endothelial cells stress fibers. PMID: 24515523
36. TXNIP is a novel molecule that links NO synthesis and NLRP3 inflammasome activation during endotoxic shock. PMID: 24098117
37. Nuclear factor-kappaB, c-Jun-N-terminal kinase, and signal transducer and activator of transcription 3 were activated much earlier and to a greater extent in Vitamin D3 up-regulated protein 1 knockout mice after partial hepatectomy. PMID: 23820201
38. demonstrated increased expression of TXNIP, LC3/LC3-II and p62 in renal tubular cells in diabetic nephropathy PMID: 24492284
39. Txnip is a critical regulator of glucose metabolism in oocytes and is involved in maintaining cytoplasmic streaming in mouse oocytes. PMID: 23976953
40. These data implicate a critical role for TXNIP in diabetes-related impairment of ischemia-mediated angiogenesis and identify TXNIP as a potential therapeutic target for the vascular complications of diabetes. PMID: 24198286
41. TXNIP is a regulator of p53 and plays a pivotal role in the maintenance of the hematopoietic cells by regulating intracellular ROS during oxidative stress. PMID: 23823478
42. TXNIP controls microRNA expression and insulin production and miR-204 is involved in beta-cell function. PMID: 23975026
43. tnxip is responsible for mediating substrate feedback inhibition and is a potential target for modulating creatine homeostasis PMID: 23715727
44. an overview of TXNIP protein and function PMID: 22750447
45. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei. PMID: 23520550
46. Data indicate that Txnip expression is increased in the hypothalamus of Gpr50-/- mice during torpor. PMID: 23584857
47. The effect of hypoxia on TXNIP expression is mediated via the inhibition of the 4E-BP1/eIF4E axis of mechanistic target of rapamycin (mTORC1). PMID: 23454121
48. Upregulation of Trx1 by Na2S therapy in the setting of heart failure sets into motion events which ultimately leads to the attenuationof left-ventricular remodeling. PMID: 23349187
49. VDUP1-deficient mice wereresistant to P. aeruginosa-induced bacteremic shock. It promoted neutrophil recruitment into the peritoneal cavity & impeded the phagocytosis of non-opsonized P. aeruginosa by the PI 3-kinase pathway in macrophages. PMID: 23246829
50. Nrf2 is a key gatekeeper of Txnip transcription, suppressing both its basal expression and MondoA-driven induction to control the thioredoxin redox signaling in diabetes. PMID: 22869588

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Cytoplasm.

Arrestin family

Ubiquitously expressed.

KEGG: mmu:56338

STRING: 10090.ENSMUSP00000102710

UniGene: Mm.410189