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  4. Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit

Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit

  • 中文名称：
    大鼠巨噬细胞炎性蛋白3α(MIP-3α/CCL20)酶联免疫试剂盒
  • 货号：
    CSB-E04669r
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    大鼠巨噬细胞炎性蛋白3α(MIP-3α/CCL20)酶联免疫试剂盒（CSB-E04669r）为双抗夹心法ELISA试剂盒，定量检测样本中的CCL20含量。CCL20是一个重要靶点。其在炎症反应、趋化免疫细胞等生理过程中发挥关键作用。研究机制方面，主要聚焦于它与相关受体结合，介导细胞迁移、激活免疫反应等，目前相关研究有助于深入了解疾病发病机制并为药物研发提供方向。适用于科研领域中对炎症机制、免疫调控或疾病模型的研究，例如通过分析细胞培养上清液、血清或组织匀浆中的CCL20动态变化，探索其在病理生理过程中的作用机制。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    Ccl20 ELISA Kit; Scya20 ELISA Kit; St38C-C motif chemokine 20 ELISA Kit; Beta-chemokine exodus-1 ELISA Kit; CC chemokine LARC ELISA Kit; CC chemokine ST38 ELISA Kit; Liver and activation-regulated chemokine ELISA Kit; Macrophage inflammatory protein 3 alpha ELISA Kit; MIP-3-alpha ELISA Kit; Small-inducible cytokine A20 ELISA Kit
  • 缩写：
    CCL20
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
  • 检测范围：
  • 灵敏度：
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

产品评价

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Ccl20 Proteins

靶点详情

  • 功能：
    Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
  • 基因功能参考文献：
    1. The results suggest a potential mechanism for the recruitment of IL-17-producing cells to degenerated intervertebral discs via a CCL20/CCR6 axis in vivo. PMID: 26704184
    2. Data show that systemic inflammatory reaction to raumatic brain injury starts before local brain response and suggest that CCL20 might play a role in promoting neuronal injury and central nervous system inflammation in response to mild TBI. PMID: 22040257
    3. the role of TGF beta 1 in high glucose-induced MIP-3 alpha expression PMID: 17664181
    4. These findings suggest that MIP-3alpha/Ccl20 plays a pivotal role in inflammatory cascades in ischemic brains, and may be a novel therapeutic target for cerebral ischemia. PMID: 19428685
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Low levels in thymus and lung.
  • 数据库链接：

    KEGG: rno:29538

    STRING: 10116.ENSRNOP00000021730

    UniGene: Rn.10722

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