Rat matrix metalloproteinase 9/Gelatinase B,MMP-9 ELISA Kit

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

1. Diacerein reduces joint damage and hypersensitivity associated with inflammation induced by complete Freund's adjuvant through the inhibition of astroglial activation and decreases the expression of TRPV1 and MMP-9 in the rat spinal cord. PMID: 26481104
2. Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys. PMID: 28805677
3. In conclusion, these results suggest that TEN exerts an anti-inflammatory effect by down-regulating the release of NO, MMP-9 and cytokines. PMID: 28392358
4. Ang II is involved in the degradation of myosin light chain kinase in pressure overload-induced cardiac hypertrophy and that this process was mediated by MMP9. PMID: 29262413
5. Jmjd3 mRNA depletion inhibited Mmp-3 and Mmp-9 gene expressions and significantly attenuated blood-spinal cord barrier permeability and the loss of tight junction proteins PMID: 27425890
6. High MMP9 expression is associated with seizures. PMID: 28501723
7. no significant relationship between plasma MMP-9 activity or aortic MMP-9 mRNA levels and the percentage of incomplete elastin lamellae or the aortic wall thickness PMID: 26547079
8. High MMP9 expression is associated with uraemic vascular calcifications. PMID: 26333546
9. that mesenchymal stem cells protect against obstruction-induced renal fibrosis, in part, by decreasing STAT3 activation and STAT3-dependent MMP-9 production PMID: 27760767
10. absent in heterotopic ossification PMID: 26919547
11. Results indicate that N-acetyl-cysteine (NAC) can effectively alleviate remifentanil-induced postoperative hyperalgesia (RIH) via powerfully inhibiting matrix metalloproteinase-9 (MMP-9)activation in dorsal root ganglia (DRGs). PMID: 28199982
12. High mmp9 expression is associated with Retinitis Pigmentosa. PMID: 27893855
13. Data suggest that increased blood pressure and decreased pup weight in ischemic model of pregnancy-induced hypertension are associated with decrease in Mmp9 homodimer and increase in Mmp9/Timp1 complex in placenta, uterus, and uterine artery; thus Mmp9 and Timp1 appear to be involved in uteroplacental/vascular remodeling in preeclampsia. (Mmp9 = matrix metalloproteinase 9; Timp1 = tissue inhibitor of metalloproteinase-1) PMID: 28506758
14. PEX1 activation of the MMP-9 promoter triggers the pro-fibrotic response directed by PEX1. PMID: 27826738
15. the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). PMID: 28157489
16. Active fraction of tubers from Pueraria tuberosa (PTY-2)significantly attenuated the severity of diabetic nephropathy (DN) by increasing the expression and activity of matrix metalloproteinase-9 (Mmp-9). PMID: 26924185
17. Therefore, the current study confirmed that MMP9 is important for the enhancement of the contractility of cerebrovascular smooth muscle cells in an in vitro rat model of subarachnoid hemorrhage PMID: 27633189
18. Naringin has anti-fatigue effects which may be attributed to its property in modulating energy metabolism and reducing serum MMP-9 concentration. PMID: 27937032
19. Alskiren attenuates signs of pulmonary fibrosis by decreasing pulmonary overexpression of MMP-9 and transforming growth factor beta1. PMID: 27154762
20. Data suggest that, as non-alcoholic fatty liver disease progresses, expression of miR-21 (mirn21 microRNA), Mmp-9 (matrix metalloproteinase 9), and Timp-1 (tissue inhibitor of metalloproteinase-1) is up-regulated in liver, peaking when liver fibrosis is first detected; miR-21 has potential as a plasma biomarker for hepatic fibrosis. PMID: 27320964
21. Atorvastatin reduced MMP9 levels in aging rat kidneys. PMID: 26680767
22. Data suggests a mechanistic involvement of MMP-9 in aggravating hypertension-induced cerebrovascular pathologies. PMID: 26800984
23. Our findings indicate that MMP9 may play an important role via inducing cell apoptosis in the development of diabetic retinopathy PMID: 26617754
24. Increased circulating MMP-9 activity is associated with resistant albuminuria and a deleterious oxidative stress environment appears to be the underlying mechanism. PMID: 26733721
25. Recombinant human BNP attenuates trauma/haemorrhagic shock-induced acute lung injury by inhibiting oxidative stress and PMID: 26852688
26. This study demonstrated that stretching activated MMP-9 gene expressions and increased the proliferation of connective tissue but did not avoid muscle fiber atrophy or induce sarcomerogenesis of denervated rat soleus muscle PMID: 25960249
27. MMP-9 expression was significantly increased in the gingiva in a model of gingival overgrowth. PMID: 25652432
28. This study has shown a potential association of matrix metalloproteinase 9 with injury of the basilar artery and can be associated with early-stage brain injury following subarachnoid hemorrhage. PMID: 25627354
29. Selective allosteric inhibition of MMP9 is efficacious in preclinical models of ulcerative colitis and colorectal cancer. PMID: 25961845
30. In the presence of acute kidney injury in severe, acute pancreatitis, the renal expression of MMP-9 and VASP is related to damage of endothelial cells in capillaries, which reached a maximum at 24 h and declined afterwards. PMID: 26264698
31. intestinal microbes with the capacity to produce collagenases and to activate host metalloproteinase MMP9 may break down collagen in the intestinal tissue contributing to anastomotic leak PMID: 25947163
32. Data show that Ash1l and EZH2 methyltransferases protein expression was significantly elevated in fibrotic liver and decreased in mutant matrix metalloproteinase-9 (mMMP-9) and human hepatocyte growth factor (hHGF) gene transfer treated fibrotic livers. PMID: 25380300
33. MMP-9 has a role in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioral alterations PMID: 25232752
34. Up-regulation of reactive oxygen species-dependent matrix metalloproteinase-9 was found from high-glucose-challenged astrocytes PMID: 24395134
35. The data indicated that early exercise significantly inhibited the ischemia-induced reduction of occludin, and an increase in MMP-9 promoted TIMP-1 expression. PMID: 23708107
36. Inspiratory resistive breathing induces MMP-9 and -12 in the lung of previously healthy rats. PMID: 25595645
37. Long term obesity creates environment promoting proliferative disorders in the prostate, leading to diffuse hyperplasia, via MMP9/VEGF pathway. PMID: 25529509
38. Cold exposure-induced MMP-9 via activation of RAS might play a critical role in the initiation of cold exposure-induced stroke during chronic hypertension and doxycycline shows protective effects against cold exposure-induced stroke. PMID: 23800500
39. Explored expression of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats. PMID: 25063292
40. Transient increases in brain MMP-9 levels are seen during cue-induced cocaine relapse. PMID: 25326689
41. MMP-9 as a potential biomarker for osteosarcoma PMID: 24704305
42. Curcumin attenuated hepatic ischemia/reperfusion-induced combined restrictive and obstructive lung disease by reducing lung inflammation and MMP-9 activity. PMID: 24815146
43. In a rat mammary neoplasm model matrix metalloproteinase 9 had consistent localization throughout cancer cells, fibroblast and stroma. PMID: 25343559
44. The location of Mmp9 and activity can be detected by means of in situ zymography and confocal microcopy, and this methodology may provide a useful tool in studies on the role of gelatinases in tooth development, maturation and in pathological conditions. PMID: 22897943
45. MMP-9 induction is required for brain astrocyte migration. PMID: 24018979
46. This study demonistrated that mmp9 throughout hippocampus at all ages but expression levels were highest during the first postnatal week. PMID: 24114974
47. CCL19/CCR7 contributes to the migration of bone marrow mesenchymal stem cells by upregulating MMP9 potentially via the PI3K/Akt pathway. PMID: 25086360
48. Matrix metalloproteinase-9, which is known to be activated by oxidative stress and S-nitrosylation of proteins, was suppressed more extensively by puerarin than losartan in diabetic rats. PMID: 24454919
49. Fish oil treatment resulted in less severe hindlimb deficits after TBI as assessed with the beam walk test, decreased cerebral IgG infiltration, and decreased TBI-induced expression of the Mmp9 gene one day after injury. PMID: 24342130
50. an overall inhibitory effect of curcumin on Gelatinase B in norepinephrine-induced hypertrophic stress in H9c2 cardiomyocytes which may contribute in the prevention of extracellular matrix remodeling. PMID: 24116115

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Secreted, extracellular space, extracellular matrix.

Peptidase M10A family

KEGG: rno:81687

STRING: 10116.ENSRNOP00000023965

UniGene: Rn.10209