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  4. NFKBIB Monoclonal Antibody

NFKBIB Monoclonal Antibody

说明书
  • 中文名称：
    NFKBIB鼠单克隆抗体
  • 货号：
    CSB-MA191867
  • 规格：
    ￥1090
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using IκB β(mAb diluted at 1:200.
    • Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using IκB βMouse mAb diluted at 1:200.
  • 其他：

产品详情

  • 产品描述：
    CUSABIO货号：CSB-MA191867 NFKBIB单克隆抗体是针对核因子κB抑制蛋白β（NFKBIB/IKBβ）研发的高特异性科研试剂，适用于人、小鼠、大鼠物种的ELISA和免疫组化（IHC）检测。该抗体基于重组蛋白免疫原制备，可特异性识别NFKBIB蛋白的56-145氨基酸区域，其作为NF-κB信号通路关键调控因子，通过抑制NF-κB核转位参与炎症反应、免疫应答及细胞增殖等重要生物学过程研究。产品经过严格验证，在ELISA实验中展现高灵敏度的抗原结合能力，适用于体外定量检测；IHC应用则支持石蜡或冰冻组织切片中目标蛋白的定位分析，为探究NF-κB通路在肿瘤、自身免疫疾病及感染性疾病中的分子机制提供可靠工具。本产品满足炎症机制研究、信号转导分析及基因表达调控等科研需求，是探索转录因子动态平衡和细胞应激反应的重要试剂。关键词：NFKBIB单抗、IKBβ检测试剂、ELISA抗体、免疫组化试剂、NF-κB通路研究。
  • Uniprot No.：
    Q15653
  • 基因名：
    NFKBIB
  • 别名：
    I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆号：
    5C3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NFKBIB antibodies

NFKBIB Proteins

靶点详情

  • 功能：
    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
  • 基因功能参考文献：
    1. The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
    2. data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
    3. our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
    4. NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
    5. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
    6. VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
    7. data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
    8. None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
    9. increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    NF-kappa-B inhibitor family
  • 组织特异性：
    Expressed in all tissues examined.
  • 数据库链接：

    HGNC: 7798

    OMIM: 604495

    KEGG: hsa:4793

    STRING: 9606.ENSP00000312988

    UniGene: Hs.9731

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