AASS Antibody

中文名称：

AASS兔多克隆抗体
货号：

CSB-PA000779
规格：

￥1090
图片：
Western Blot analysis of HeLa cells using AASS Polyclonal Antibody

Western Blot analysis of 293 NIH-3T3 A549 cells using AASS Polyclonal Antibody
其他：

产品详情

Uniprot No.：

Q9UDR5
基因名：

AASS
别名：

AASSAlpha-aminoadipic semialdehyde synthase antibody; mitochondrial antibody; LKR/SDH) [Includes: Lysine ketoglutarate reductase antibody; LKR antibody; LOR antibody; EC 1.5.1.8); Saccharopine dehydrogenase antibody; SDH antibody; EC 1.5.1.9)] antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human AASS.
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
产品提供形式：

Liquid
应用范围：

WB, ELISA

推荐稀释比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
基因功能参考文献：
1. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
2. Mitochondrial NADPH is crucial for AASS function PMID: 24847004
3. Hyperlysinemia is caused by mutations in AASS PMID: 23570448
4. Isolation and characterization of the mouse ortholog. PMID: 10567240
相关疾病：

Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
亚细胞定位：

Mitochondrion.
蛋白家族：

AlaDH/PNT family; Saccharopine dehydrogenase family
组织特异性：

Expressed in all 16 tissues examined with highest expression in the liver.
数据库链接：

HGNC: 17366

OMIM: 238700

KEGG: hsa:10157

STRING: 9606.ENSP00000377040

UniGene: Hs.156738