ARRB1 Antibody

1. The antitumor effect of miR296 in CRC are at least in part due to the inactivation of the RAC-alpha serine/threonine-protein kinase (AKT) signaling pathway induced by the suppression of ARRB1 expression. PMID: 30365090
2. Beta-arrestin interacting with unphosphorylated ADRB2 fails to activate mitogen-activated protein kinase (MAPK) signaling and prolonged interaction of beta-arrestin with ADRB2 promoted the sorting of ADRB2 to lysosomes. PMID: 29330504
3. Beta-arrestin-1 expression is associated with a poor prognosis in serous ovarian cancer patients.Beta-arrestin-1 role in the invadopodian function. PMID: 29439204
4. Conformation of ADRB2 induced by the phosphorylation resulted in beta-arrestin binding. PMID: 29335412
5. Bulky Phe substitution of Cys-147 in human arrestin-1 likely causes rod degeneration due to reduced stability of the protein, which induces unfolded protein response in expressing cells PMID: 29305604
6. Results indicate a mechanism for beta-arrestin1 in the regulation of the prostate cancer procession through inhibiting FOXO3a. PMID: 29676828
7. Studies indicate that the interaction of activated and phosphorylated GPCRs with the multifunctional adaptor proteins beta-arrestins (betaarrs) is crucial for regulation of their signaling and functional outcomes [Review]. PMID: 28651823
8. The results show that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 and Cdc42. PMID: 28749339
9. These results provide clear evidence that CXCR4- or CCR5-beta-arrestin complexes induce receptor endocytosis and signaling in the absence of G protein coupling and ligand-induced conformational changes of the receptor. PMID: 28733085
10. Our results identify a new molecular mechanism involving miR-326 and Arrb1 as regulators of Sonic hedgehog medulloblastoma Cancer stem cells . Specifically, low levels of Arrb1 and miR-326 trigger and maintain Hh/Gli signaling and self-renewal PMID: 28716052
11. This work demonstrates that the expression of FSHR and LHCGR can be induced in hGL5 cells but that the FSHR-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR-cAMP-PKA-induced apoptosis. PMID: 27502035
12. Arrb1 reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling. PMID: 27195676
13. This study reveals contrasting abilities of IGF-1R to interact with each b-arrestin isoform, depending on the presence of the ligand and demonstrates the antagonism between the two b-arrestin isoforms in controlling IGF-1R expression and function, which could be developed into a practical anti-IGF-1R strategy for cancer therapy. PMID: 28581517
14. Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins. PMID: 27188791
15. findings suggest that knockdown of beta-arrestin 1 can suppress glioblastoma multiforme cell proliferation, invasion and glycolysis by inhibiting Src signaling PMID: 28442265
16. the depleted beta-Arrestin1 reduced the interaction of P300 with Sp1, thus to reduce Sp1 binding to hTERT promoter, downregulate hTERT transcription, decrease telomerase activity, shorten telomere length, and promote Reh cell senescence. PMID: 28425985
17. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
18. The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation. PMID: 27493245
19. These results were consistent with those seen for beta2-AR. Thus, both beta-arrs negatively control AM1 receptor internalization, which depends on the C-tail of CLR. PMID: 28427767
20. Results indicate a mechanism of beta-arrestin1 in modulating epithelial-mesenchymal transition (EMT) and glycogen synthase kinase 3 beta (GSK-3beta)/beta-catenin signaling in prostate cancer, and suggest that assessment of beta-arrestin1 may provide a potential therapeutic target for prostate cancer. PMID: 27620488
21. The downregulation of beta-arrestins 1/2 in saphenous vein endothelial cells (SVECs) prevented the shear stress-induced rise in levels of phosphorylation of Akt and endothelial nitric oxide synthase (eNOS, Serine 1177). PMID: 28062183
22. results suggest that ARRB1 plays an essential role in NK1R-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1-mediated signaling via NK1R may have potential significance for therapeutic strategies targeting glioblastoma. PMID: 28341744
23. The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner. PMID: 27789711
24. distinct ligands can leverage specific sequence elements on microR to regulate receptor endocytic lifetimes and the magnitude of arrestin-mediated signaling. PMID: 28153854
25. CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R. PMID: 27895162
26. Low expression of ARRB1 is associated with lung cancer. PMID: 28035404
27. In non-small cell lung cancer patients, the loss expression of beta-arrestin1 was frequently observed, and beta-arrestin1 expression was significantly correlated with the smoking index and E-cadherin expression, which all indicated beta-arrestin1's significant clinicopathologic role PMID: 26293896
28. beta-arrestins regulate oxidative stress in a Nox4-dependent manner and increase fibrosis in heart failure. PMID: 26449263
29. These results indicated that b-arr1 regulated ER stress/PUMA-induced mucosal epithelial apoptosis through suppression of the TNF-a/p65/iNOS signaling pathway activation and that b-arr1 is a potential therapeutic target for Portal hypertensive gastropathy. PMID: 26119788
30. The nuclear accumulation of beta-arrestin 1 following TLR2 activation promote H4 acetylation at specific target gene promoters and may thus affect transcription of target genes in BM CD34+ cells. PMID: 26708616
31. beta-arrestins functional involvement in myogenesis is presented. PMID: 26211463
32. The identified receptor-phospho-selective mechanism for arrestin conformation and the spacing of the multiple phosphate-binding sites in the arrestin enable arrestin to recognize plethora phosphorylation states of numerous GPCRs. PMID: 26347956
33. Data suggest that ARRB1 enhances hepatocellular carcinogenesis by inflammation-mediated Akt signaling. PMID: 26077142
34. We conclude that beta-arrestin1 had a high expression in lung adenocarcinoma and beta-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with lung adenocarcinoma. PMID: 26097560
35. Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin proteins play key roles in their regulation. PMID: 25766502
36. After eight and 12 weeks of treatment with mirtazapine, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 haplotype 1 than in those without haplotype 1 PMID: 25294870
37. analysis of how NK1 receptor Gs versus Gq proteins and beta-arrestin signaling is determined by interactions in the water hydrogen bond network PMID: 26269596
38. Multivariate analysis using the Cox regression model confirmed that co-expression of nuclear beta-arrestin1 and p65 was an independent prognostic factor for tumor progression (p = 0.008 PMID: 25820700
39. Beta-arrestins regulate human cardiac fibroblast transformation in to a myofibroblast phenotype in ventricular remodeling. PMID: 25134464
40. The potential role of ET-1/ETAR in promoting NF-kappaB signalling in EOC cells through beta-arr-1 recruitment, was examined. PMID: 24530737
41. High ARBB1 expression is associated with metastasis in non-small cell lung cancers. PMID: 25401222
42. A new role for Arr2 in the expression and activation of Androgen receptor and its potential relevance as a target for therapeutic intervention and monitoring of disease progression. PMID: 25109335
43. Stimulation of multiple non-small cell lung cancer cell lines with nicotine led to enhanced recruitment of beta-arrestin-1 and E2F1 on vimentin PMID: 25600647
44. IL6 stimulated SOD2 expression that, at least partially, contributed to the low level of ROS that would likely result in a sustained increase in the expression of IGF-1R through abolishment of beta-arrestin1 in docetaxel resistant cells. PMID: 24939178
45. our findings reveal the existence of a novel mechanism by which ETAR/beta-arr1 signaling is integrated with the Wnt/beta-catenin pathway to sustain chemoresistance in epithelial ovarian cancer, and they offer a solid rationale for clinical evaluation PMID: 25377471
46. TSH stimulated translocation of beta-arrestin-1 to TSHR. beta-arrestin-1 downregulation inhibited TSH-stimulated phosphorylation of ERK1/2, p38alpha, and AKT1. Activatory signals mediated by beta-arrestin-1 cause TSH-enhanced osteoblast differentiation in U2OS cells. PMID: 24723693
47. the primary function of betaARRs and ECE-1 in SP-dependent inflammatory signaling is to promote resensitization, which allows the sustained NK1R signaling from the plasma membrane that drives inflammation PMID: 24898255
48. A novel function of beta-arrestin1 binding to EZH2 to promote chronic myeloid leukemia progression by regulating BCR/ABL-histone H4 acetylation. PMID: 24937675
49. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. PMID: 24837709
50. The transient up-regulation of miR-525-3p, and the resultant repression of its direct targets ARRB1, TXN1 and HSPA9, is required for cell survival following irradiation. PMID: 24147004

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HGNC: 711

OMIM: 107940

KEGG: hsa:408

STRING: 9606.ENSP00000409581

UniGene: Hs.503284