ARRB2 Antibody

1. Pre-treatment with beta-arrestin2 agonists was shown to inhibit the AMPK/mTOR signaling pathway, and to inhibit autophagy by restoring the levels of beta-arrestin2 in BEAS-2B cells. These changes were reversed with the knockdown of beta-arrestin2, indicating that beta-arrestin2 suppressed autophagy through the AMPK-mTOR signaling pathway. PMID: 30355935
2. Extracellular alpha-synuclein induces sphingosine S1P1R uncoupled from inhibitory G-protein leaving beta-arrestin signal intact. PMID: 28300069
3. Results showed that significantly higher expression of betaarrestin2 was observed in colorectal cancer tissues compared with normal colon tissues. PMID: 29620228
4. overexpression of beta-arrestin2 can inhibit the growth of renal cell carcinoma (RCC) cells in vitro, and beta-arrestin2 acts as a tumor suppressor gene in RCC; the main mechanism may directly suppress the phosphorylation of IkBa and indirectly suppress NFkB PMID: 28485809
5. Study investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to antidepressant treatment in a sample of 569 patients with a major depressive episode treated for 6months: GG/GT patients for rs4522461 and AA/AC patients for rs4790694 had a lower response. PMID: 29031912
6. Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-linked polyubiquitylation without affecting its stability. PMID: 29515120
7. USP33 may indirectly regulate the degradation and recycling of CXCR4 through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis. PMID: 27835898
8. Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R. PMID: 27468652
9. the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified. PMID: 27818291
10. Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors. PMID: 28169830
11. Data indicate that a constitutively monomeric CXCL12 variant reproduced the G protein-dependent and beta-arrestin-dependent responses that are associated with normal CXCR4 signaling and lead to cell migration. PMID: 28325822
12. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In PMID: 27561318
13. CCR5 is highly expressed in active inflammatory bowel disease, and it has positive correlation with lymphocyte grade and negative correlation with expression of beta-arrestin2. PMID: 28140695
14. Data suggest that PAR4 and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 recruitment to endosomes and up-regulation of Akt signaling; activation of PAR4 but not of P2Y12 drives internalization of the PAR4-P2Y12 heterodimer. (PAR4 = protease-activated receptor 4; P2Y12 = purinergic receptor P2Y, G-protein coupled, 12 protein; Akt = proto-oncogene protein c-akt) PMID: 28652403
15. Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway. PMID: 27523794
16. RACK1 and beta-arrestin2 inhibit the dimerization of PDE4D5. PMID: 26257302
17. Suggest that fenoterol inhibited AICAR-induced AMPK alpha1 activation and TNF-alpha release through beta-arrestin-2 in THP-1 cells. PMID: 27657826
18. Results demonstrate that betaArr2 signaling may be an important pathway for TAAR1 function and that the activation of the TAAR1-D2R complex negatively modulates GSK3b signaling PMID: 26372541
19. Role for engagement of BARR2 by the transactivated EGFR in agonist-specific regulation of delta receptor activation of ERK1/2 PMID: 26211551
20. Data suggest that thrombin can directly activate PAR2 vasorelaxation, signal transduction (stimulating both calcium and MAP kinase responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 and 2). PMID: 26957205
21. a beta-arrestin signalling cycle that is catalytically activated by the GPCR and energetically coupled to the endocytic machinery PMID: 26829388
22. The rare variants in ARRB2 were significantly associated with smoking status. PMID: 25450229
23. analysis of the crystal structure of the rhodopsin-arrestin complex PMID: 26467309
24. In this study, we aimed to exploit an in vitro model system of BPH in order to better understand the mechanisms of alpha-AR signaling in prostatic hyperplasia. PMID: 26850854
25. interaction of beta-arrestin with GPCRs, and the beta-arrestin conformational changes in real time and in living human cells, using a series of fluorescence resonance energy transfer (FRET)-based beta-arrestin2 biosensors PMID: 27007855
26. ARRB2 is not upregulated in inflammation-associated hepatocellular carcinoma (HCC) and paracancerous tissues. PMID: 26077142
27. Beta-arrestin 2 promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis. PMID: 25354317
28. MTS assay revealed that silencing of beta-arrestin 2 increased the sensitivity to anti-cancer drugs to some extent. On the other hand, overexpression of beta-arrestin 2 had the opposite effects. PMID: 25973019
29. In a mouse model of Marfan syndrome, BARR2 contributes to thoracic aortic aneurysm formation by regulating ERK1/2-dependent expression of proaneurysmal genes and proteins downstream of the AT1aR. PMID: 26371162
30. GPCR cell-surface expression is regulated by receptor sequestration in response to beta-arrestin-2 phosphorylation by ERK1/2 PMID: 26324936
31. GPR40 functions via both G protein-mediated and beta-arrestin-mediated mechanisms; endogenous and synthetic ligands differentially engage these pathways to promote insulin secretion. PMID: 26157145
32. identified a novel role for beta-arrestin2 in the modulation of the castration-resistant prostate cancer progress through FOXO1 PMID: 25752515
33. Study demonstrates that the minor allele of rs1045280, the tSNP of ARRB2, significantly increases late-onset Alzheimer's disease risk in a Northern Han Chinese population, implying that ARRB2 may represent a susceptibility gene PMID: 24635845
34. arrestin-3 and GRK2 play an essential role in the regulation of agonist-mediated GPR40 internalization, but are not involved in the regulation of constitutive GPR40 internalization. PMID: 25038452
35. SUMOylation is a novel mechanism in the regulation of beta-arrestin 2-mediated IL-1R/TRAF6 signaling PMID: 25425640
36. The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to beta-arrestin-2 recruitment. PMID: 24386388
37. Decreased beta-arrestin expression is associated with breast cancer. PMID: 24568448
38. Phosphorylation and structural elements within the C-terminal tail of FFA4 allow for the recruitment of arrestin-3. PMID: 24817122
39. a novel adaptor beta-arrestin 2 that associates with phosphorylated TIGIT for further recruitment of SHIP1 (SH2-containing inositol phosphatase 1) through the ITT-like motif. PMID: 24817116
40. GPR43 modulates NF-kappaB activity via beta-arrestin 2. PMID: 23985900
41. CRF2(a) receptor desensitization is dependent on beta-arrestin2 recruitment. PMID: 23820308
42. CCR1.beta-arrestin-2 complex may be related to a potential scavenging function of the receptor, which may be important for maintenance of chemokine gradients and receptor responsiveness in complex fields of chemokines during inflammation. PMID: 24056371
43. Taken together, the participation of 5-HT1A and FGFR1 homodimers and recruitment of beta-arrestin2 was demonstrated in the FGFR1-5-HT1A heteroreceptor complexes upon agonist treatments. PMID: 24157794
44. Beta-arr2 binding is only required for agonist-induced internalization of the CB1 receptor. PMID: 23541635
45. beta-arrestin 2 and CCR7 and PI3K phosphorylation have a role in bisoprolol reversed epinephrine-mediated inhibition of cell migration, in dendritic cells loaded with cholesterol PMID: 23290307
46. Social anhedonia mutant DISC-1 mouse model has reduced levels of beta-arrestin-1,2 in the nucleus accumbens. PMID: 23011268
47. beta-arrestin2-PDE4D5 complex allowed the recruitment of Epac1 to beta2AR and induced a switch from beta2AR non-hypertrophic signaling to a beta1AR-like pro-hypertrophic signaling cascade. PMID: 23266473
48. Arf (ADP-ribosylation factor) GAP (GTPase-activating protein) AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors, co-localizing with overexpressed beta2AR and trapping beta2AR in the perinuclear region. PMID: 23527545
49. Beta 2 adrenergic receptor endocytosis requires beta-arrestin2 but not ARRDC3. PMID: 23208550
50. The interaction of TbetaRII with betaarrestin2 is involved in modulating TGFbeta signal transduction, as loss of betaarrestin2 increases the phosphorylation of p38 and modestly affects pSmad levels. PMID: 23069267

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HGNC: 712

OMIM: 107941

KEGG: hsa:409

STRING: 9606.ENSP00000269260

UniGene: Hs.435811