Acetyl-HIST1H2BB (K16) Antibody

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) HIST1H2BB Polyclonal antibody
Uniprot No.：

P33778
基因名：

HIST1H2BB
别名：

HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Peptide sequence around site of Acetyl-Lys (16) derived from Human Histone H2B type 1-B
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, ICC, IF, ChIP

推荐稀释比：

Application	Recommended Dilution
ICC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
Native Chromatin immunoprecipitation (ChIP) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
基因功能参考文献：
1. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID: 29643390
2. RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID: 26854224
3. RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID: 21362548
亚细胞定位：

Nucleus. Chromosome.
蛋白家族：

Histone H2B family
数据库链接：

HGNC: 4751

OMIM: 602803

KEGG: hsa:3018

STRING: 9606.ENSP00000350580

UniGene: Hs.553494