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中文名称：
BAI2兔多克隆抗体
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货号：
CSB-PA066517
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规格：
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图片：
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The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA066517(ADGRB2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA066517(ADGRB2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
产品详情
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Uniprot No.：
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基因名：
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别名：
ADGRB2 antibody; BAI2Adhesion G protein-coupled receptor B2 antibody; Brain-specific angiogenesis inhibitor 2 antibody
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宿主：
Rabbit
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反应种属：
Human,Mouse
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免疫原：
Synthetic peptide of Human ADGRB2
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免疫原种属：
Homo sapiens (Human)
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标记方式：
Non-conjugated
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抗体亚型：
IgG
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纯化方式：
Antigen affinity purification
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式：
Liquid
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应用范围：
ELISA,IHC
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推荐稀释比：
| Application |
Recommended Dilution |
| ELISA |
1:1000-1:2000 |
| IHC |
1:25-1:100 |
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition.
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基因功能参考文献：
- These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease. PMID: 28891236
- This is the first study reporting BAI2 as an interaction partner of GIP. PMID: 21787750
- BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID: 20367554
- involvement of BAI2 in the ischemia-induced brain angiogenesis PMID: 12218411
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亚细胞定位：
Cell membrane; Multi-pass membrane protein.
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蛋白家族：
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
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组织特异性：
Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
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数据库链接：
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