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  4. BZLF2 Antibody, FITC conjugated

BZLF2 Antibody, FITC conjugated

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说明书
  • 中文名称：
    BZLF2兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA365876LC01EFA
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Epstein-Barr virus BZLF2 Polyclonal antibody
  • Uniprot No.：
    P03205
  • 基因名：
    BZLF2
  • 别名：
    BZLF2Glycoprotein 42 antibody; gp42) [Cleaved into: Soluble gp42] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Epstein-Barr virus
  • 免疫原：
    Recombinant Epstein-Barr virus Glycoprotein 42 protein (34-223AA)
  • 免疫原种属：
    Epstein-Barr virus
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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BZLF2 antibodies

靶点详情

  • 功能：
    Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor-class II-peptide interaction.; Soluble gp42 inhibits HLA class II-restricted antigen presentation to T-cells through binding to immature and mature HLA class II complexes. ...显示更多
  • 基因功能参考文献：
    1. gp42 mutants bound to gH/gL and HLA class II, but not wild-type gp42 or cleavage mutant of gp42; using purified gp42, gH/gL, and HLA, found these proteins associate 1:1:1 suggesting gp42 dimerization or multimerization does not occur or is transient PMID: 21550622
    2. reveal distinct functional requirements for gH/gL and gp42 complexes in Epstein-Barr virus-mediated membrane fusion PMID: 16973550
    3. This screening demonstrates that LF2 specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and IFN-mediated immunity. PMID: 18987133
    4. Enhanced secretion of gp42 promoted fusion with B lymphocytes, and mutation of the site of gp42 cleavage inhibited membrane fusion activity. PMID: 19369343
  • 亚细胞定位：
    Virion membrane. Host membrane; Single-pass membrane protein.
  • 蛋白家族：
    Epstein barr virus gp42 family
  • 数据库链接：

    KEGG: vg:3783745

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