CACNB1 Antibody

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) CACNB1 Polyclonal antibody
Uniprot No.：

Q02641
基因名：

CACNB1
别名：

CAB1 antibody; CACB1_HUMAN antibody; CACNB1 antibody; CACNLB1 antibody; Calcium channel L type beta 1 polypeptide antibody; Calcium channel voltage dependent beta 1 subunit antibody; Calcium channel voltage-dependent subunit beta 1 antibody; CCHLB1 antibody; Dihydropyridine sensitive L type calcium channel beta 1 subunit antibody; MGC41896 antibody; Voltage dependent L type calcium channel beta 1 subunit antibody; Voltage-dependent L-type calcium channel subunit beta-1 antibody
宿主：

Rabbit
反应种属：

Human, Mouse
免疫原：

Recombinant Human Voltage-dependent L-type calcium channel subunit beta-1 protein (429-598AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产品提供形式：

Liquid
应用范围：

ELISA, WB, IHC

推荐稀释比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
基因功能参考文献：
1. CACNB1, encoding cardiac L-type calcium channel beta 1 subunit, is a potential target for microRNA-328 in transgenic mice. PMID: 21098446
2. Data show that the length-dependent mechanism of modulating inactivation kinetics of beta(2) calcium channel subunits can be confirmed and extended to the beta(1) calcium channel subunit. PMID: 19821165
亚细胞定位：

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.
蛋白家族：

Calcium channel beta subunit family
组织特异性：

Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
数据库链接：

HGNC: 1401

OMIM: 114207

KEGG: hsa:782

STRING: 9606.ENSP00000377840

UniGene: Hs.635