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中文名称：
CIR1兔多克隆抗体
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货号：
CSB-PA773051DSR1HU
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规格：
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图片：
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Western blot
All lanes: TMOD1 antibody at 2.84μg/ml
Lane 1: PC-3 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 24 kDa
Observed band size: 53 kDa
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Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA773051DSR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA773051DSR1HU at dilution of 1:100
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其他：
产品详情
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产品名称：
Rabbit anti-Homo sapiens (Human) CIR1 Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：
CIR1 antibody; CIRCorepressor interacting with RBPJ 1 antibody; CBF1-interacting corepressor antibody; Recepin antibody
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宿主：
Rabbit
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反应种属：
Human
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免疫原：
Recombinant Human Corepressor interacting with RBPJ 1 protein (1-160AA)
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免疫原种属：
Homo sapiens (Human)
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标记方式：
Non-conjugated
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克隆类型：
Polyclonal
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抗体亚型：
IgG
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纯化方式：
Antigen Affinity Purified
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式：
Liquid
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应用范围：
ELISA, WB, IHC
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推荐稀释比：
| Application |
Recommended Dilution |
| WB |
1:1000-1:5000 |
| IHC |
1:20-1:200 |
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
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基因功能参考文献：
- three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
- identified as a PAP-1 binding protein and as a splicing factor PMID: 15652350
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亚细胞定位：
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
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组织特异性：
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
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数据库链接：
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