DLL3 Antibody, Biotin conjugated
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中文名称：DLL3兔多克隆抗体, Biotin偶联
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货号：CSB-PA882142LD01HU
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规格：￥880
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其他：
产品详情
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产品名称：Rabbit anti-Homo sapiens (Human) DLL3 Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：Delta Drosophila like 3 antibody; Delta like 3 Drosophila antibody; Delta like 3 homolog Drosophila antibody; Delta like 3 protein antibody; Delta like protein 3 precursor antibody; Delta-like protein 3 antibody; Delta3 antibody; Dll3 antibody; DLL3_HUMAN antibody; Drosophila Delta homolog 3 antibody; SCDO1 antibody; SCOD1 antibody; Spondylocostal dysostosis autosomal recessive antibody
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宿主：Rabbit
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反应种属：Human
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免疫原：Recombinant Human Delta-like protein 3 protein (27-492AA)
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免疫原种属：Homo sapiens (Human)
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标记方式：Biotin
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克隆类型：Polyclonal
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抗体亚型：IgG
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纯化方式：>95%, Protein G purified
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浓度：It differs from different batches. Please contact us to confirm it.
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保存缓冲液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式：Liquid
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应用范围：ELISA
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Protocols：
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储存条件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶点详情
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功能：Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
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基因功能参考文献：
- these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
- Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
- our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
- The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
- Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
- DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
- We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
- mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
- no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
- The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613
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相关疾病：Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
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亚细胞定位：Membrane; Single-pass type I membrane protein.
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数据库链接：
