FZD10 Antibody

产品详情

Uniprot No.：

Q9ULW2
基因名：

FZD10
别名：

FZD10; Frizzled-10; Fz-10; hFz10; FzE7; CD antigen CD350
宿主：

Rabbit
反应种属：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human Frizzled-10.
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
产品提供形式：

Liquid
应用范围：

WB, ELISA

推荐稀释比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathway...显示更多
基因功能参考文献：
1. there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10 PMID: 19134005
2. FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas PMID: 19137009
亚细胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor Fz/Smo family
组织特异性：

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe an
数据库链接：

HGNC: 4039

OMIM: 606147

KEGG: hsa:11211

STRING: 9606.ENSP00000229030

UniGene: Hs.31664