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  4. FZD9 Antibody

FZD9 Antibody

说明书
  • 中文名称：
    FZD9兔多克隆抗体
  • 货号：
    CSB-PA002582
  • 规格：
    ￥1090
  • 图片：
    • Western Blot analysis of COS7 cells using Frizzled-9 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O00144
  • 基因名：
    FZD9
  • 别名：
    FZD9; FZD3; Frizzled-9; Fz-9; hFz9; FzE6; CD antigen CD349
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Frizzled-9.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
    Western Blotting (WB) Protocol
    Immunofluorescence (IF) Protocol
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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FZD9 antibodies

FZD9 Proteins

靶点详情

  • 功能：
    Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to ...显示更多
  • 基因功能参考文献：
    1. the present study indicated that the methylation profile of the FZD9 gene corresponded to that of a candidate tumorsuppressor gene in acute myeloid leukemia. PMID: 27314612
    2. The presence of nanog, Oct-4, SSEA-1, and SSEA-4 suggests that periodontal ligament mesenchymal stem cells are less differentiated than bone marrow-derived MSCs, and the frizzled-9/Wnt pathway is important in proliferation and differentiation. PMID: 20458727
    3. The activity of the Sprouty4 promoter is increased by Wnt7A/Fzd9 signaling through peroxisome proliferator-activated receptor gamma in lung cancer cells. PMID: 20501643
    4. The presence of nanog, Oct-4, SSEA-1, and SSEA-4 suggests that periodontal ligament mesenchymal stem cells are less differentiated than bone marrow-derived MSCs, and that the frizzled-9/Wnt pathway is important in proliferation and differentiation. PMID: 20458727
    5. transfection of Fzd-9 into a Wnt-7a-insensitive NSCLC cell line established Wnt-7a sensitivity PMID: 15705594
    6. Aberrant DNA methylation of frizzled 9 protein is associated with myelodysplastic syndrome progression to acute myeloid leukemia. PMID: 18832655
    7. SiRNA of frizzled-9 suppresses proliferation and motility of hepatoma cells. PMID: 19724923

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor Fz/Smo family
  • 组织特异性：
    Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells.
  • 数据库链接：

    HGNC: 4047

    OMIM: 601766

    KEGG: hsa:8326

    STRING: 9606.ENSP00000345785

    UniGene: Hs.647029

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