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  4. GALR2 Antibody

GALR2 Antibody

说明书
  • 中文名称：
    GALR2兔多克隆抗体
  • 货号：
    CSB-PA627841
  • 规格：
    ￥1090
  • 图片：
    • Western blot analysis of 1) Rat Brain Tissue, 2)Mouse Brain Tissue with GALR2 Rabbit pAb diluted at 1:2,000.
  • 其他：

产品详情

  • Uniprot No.：
    O43603
  • 基因名：
    GALR2
  • 别名：
    GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1000
  • Protocols：
    Western Blotting (WB) Protocol
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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GALR2 antibodies

GALR2 Proteins

靶点详情

  • 功能：
    Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
  • 基因功能参考文献：
    1. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
    2. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
    3. The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer PMID: 24568968
    4. In HEp-2 cells, GALR2-mediated apoptosis was caspase-independent. PMID: 24168112
    5. Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels. PMID: 24602615
    6. The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma. PMID: 24122450
    7. galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck PMID: 21345369
    8. Elevated expression of galanin receptors in childhood neuroblastic tumors PMID: 11867941
    9. study indicates that a high level of GalR2 galanin receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells PMID: 14592962
    10. There was no effect of GALR2 on alcoholism risk. PMID: 17083333
    11. point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma PMID: 18272487

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
  • 数据库链接：

    HGNC: 4133

    OMIM: 603691

    KEGG: hsa:8811

    STRING: 9606.ENSP00000329684

    UniGene: Hs.666366

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