GIT1 Antibody

1. There is significant interaction effects of the GIT1 and DRD4 gene variants on impulsivity in Attention Deficit Hyperactivity Disorder. PMID: 28948080
2. We show that GIT1, which also contains an ANK domain, inhibits the Notch1-Dll4 signaling pathway by competing with Notch1 ANK domain for binding to RBP-J in stalk cells PMID: 27926858
3. we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease PMID: 27182061
4. interactions between Cat-1 and its binding partner paxillin are necessary to ensure sufficient Akt activation so that cancer cells are able to grow under anchorage-independent conditions PMID: 28100775
5. In astrocytes and neural stem cells, we identified G-protein-coupled receptor kinase-interacting protein 1 (GIT1) as a novel mTOR-binding protein, creating a unique mTOR complex lacking Raptor and Rictor PMID: 27340174
6. miR-195 inhibits chondrocyte migration through targeted regulation of GIT1 expression. PMID: 27922692
7. MiR-491 has a role in attenuating cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-kappaB-mediated EMT PMID: 26188902
8. Data show that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR-138 binding sites in their 3' untranslated region (3'UTRs). PMID: 26283050
9. Data show association of G protein-coupled receptor kinase-interacting protein 1 (GIT1), p21-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) with centrosomes. PMID: 27012601
10. Results suggested that cyclic phosphorylation-dephosphorylation at Tyr- 554 of Git1 was crucial for dynamic interactions between Git1 and paxillin/Hic-5 in order to ensure coordinated cell motility. PMID: 25742295
11. GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain. PMID: 25284783
12. Results show that GIT1 is targeted by miR-149 to suppress breast cancer cell migration/invasion and metastasis. PMID: 24608434
13. miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. PMID: 24335959
14. GIT1-cortactin association through GIT1-Spa homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis. PMID: 24265417
15. GIT1 SNP rs550818 is not associated with ADHD in the Brazilian sample. PMID: 22897819
16. novel roles for Cat-1 and its interactions with the Arf GTPases and paxillin in oncogenic transformation. PMID: 22807447
17. Rac1 affects small GTPase Arf6 via the Arf GTPase-activating protein, GIT1, as key downstream components of the signaling pathway underlying Ras-induced non-apoptotic cell death. PMID: 20713492
18. an intronic single-nucleotide polymorphism in GIT1, the minor allele of which causes reduced GIT1 expression, shows a strong association with ADHD susceptibility PMID: 21499268
19. The CC domain of ERK1/2 is necessary for binding to GIT1, for ERK1/2 activation in focal adhesions, and for cell spreading and migration. PMID: 19947948
20. MYO18A is a novel binding partner of the PAK2/betaPIX/GIT1 complex and suggest that MYO18A may play an important role in regulating epithelial cell migration via affecting multiple cell machineries. PMID: 19923322
21. GIT1 functions in a motile, multi-molecular signaling complex that regulates membrane protrusions and cell migration. PMID: 11896197
22. GIT1 is a novel regulator of PLCgamma function that mediates PLCgamma activation by c-Src and integrates signal transduction by GPCRs and TKRs PMID: 14523024
23. GIT1 is a novel mediator in agonist-dependent signaling in ECs. GIT1 is involved in cell shape changes and may have a role as a negative feedback regulator that augments recovery of cell contraction. PMID: 15016733
24. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington disease. PMID: 15383276
25. GIT1 has a role as a scaffold for ERK1/2 activation in focal adhesions PMID: 15923189
26. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between the plasma membrane and endosomes. PMID: 16598076
27. Mass spectrometry was to used to generate a phosphorylation map og GIT1. PMID: 16825424
28. Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability. PMID: 17429073
29. GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. PMID: 17467235
30. The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1. PMID: 17562871
31. tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin PMID: 18211801
32. GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. PMID: 19023093
33. Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. PMID: 19494130
34. Cloning of human GIT1 cDNA, and demonstration of GIT1 interaction with PIX and paxillin proteins. PMID: 10896954

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HGNC: 4272

OMIM: 608434

KEGG: hsa:28964

STRING: 9606.ENSP00000378338

UniGene: Hs.514051