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  4. GSDME Antibody

GSDME Antibody

说明书
  • 中文名称：
    GSDME兔多克隆抗体
  • 货号：
    CSB-PA006766ESR1HU
  • 规格：
    ￥440
  • 图片：
    • Western blot
      All lanes: Non-syndromic hearing impairment protein 5 antibody at 10μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55, 11, 37 kDa
      Observed band size: 55 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006766ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006766ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA006766ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GSDME Polyclonal antibody
  • Uniprot No.：
    O60443
  • 基因名：
    GSDME
  • 别名：
    2310037D07Rik antibody; 4932441K13Rik antibody; Deafness, autosomal dominant 5 antibody; Deafness, autosomal dominant 5 protein antibody; DFNA5 antibody; DFNA5 gene antibody; DFNA5_HUMAN antibody; Dfna5h antibody; EG14210 antibody; Fin15 antibody; ICERE 1 antibody; ICERE-1 antibody; Inversely correlated with estrogen receptor expression 1 antibody; Non-syndromic hearing impairment protein 5 antibody; Nonsyndromic hearing impairment protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Gasdermin-E protein (1-260AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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GSDME antibodies

GSDME Proteins

靶点详情

  • 功能：
    Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively. After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanom...显示更多
  • 基因功能参考文献：
    1. DFNA5 variant is associated with tobacco- and HPV-mediated oral oncogenesis. PMID: 30091681
    2. DFNA5 methylation shows strong potential as a biomarker for detection of breast cancer. Slightly increased methylation in histologically normal breast tissue surrounding the tumor suggests that it may be a good early detection marker. PMID: 28404884
    3. In conclusion, our findings firstly revealed that GSDME switches chemotherapy drug-induced caspase-3 dependent apoptosis into pyroptosis in gastric cancer cells. PMID: 29183726
    4. findings suggest that caspase-3 activation can trigger necrosis by cleaving GSDME and offer new insights into cancer chemotherapy PMID: 28459430
    5. Genetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL). PMID: 26400775
    6. Study identified a novel DFNA5 mutation IVS8+1 delG in a Chinese family which led to skipping of exon 8. This is the sixth DFNA5 mutation relates to hearing loss and the second one in DFNA5 intron 8. PMID: 26365971
    7. We identified a novel c.991-2A>G mutation in DFNA5 which again may lead to exon 8 skipping at the mRNA level. PMID: 24933359
    8. DFNA5 deletion mutation is associated with autosomal dominant hereditary hearing loss in Japanese families. PMID: 24506266
    9. DFNA5 protein expression in hepatocellular carcinoma cells was significantly lower than that in normal cells. PMID: 24154762
    10. DFNA5 is composed of two domains, separated by a hinge region. The first region induces apoptosis when transfected in HEK293T cells, the second region masks and probably regulates this apoptosis inducing capability PMID: 21522185
    11. A mutation in DFNA5 leads to a type of hearing loss that closely resembles the frequently observed age-related hearing impairment. PMID: 21805831
    12. A founder effect was demonstrated for the mutation of the DFNA5 gene casusing hearing loss in East Asians. PMID: 19911014
    13. no significant linkage between age-related hearing impairment (ARHI) and microsatellite markers from the DFNA5 region; there exists no strong association between DFNA5 and ARHI PMID: 12461698
    14. Here, we report another mutation in DFNA5, a CTT deletion in the polypyrimidine tract of intron 7. PMID: 14559215
    15. A novel DFNA5 mutation was found in a Dutch family, of which 37 members were examined. PMID: 14676472
    16. These results suggest that DFNA5 plays a role in the p53-regulated cellular response to genotoxic stress probably by cooperating with p53. PMID: 16897187
    17. description of a DFNA5 mutation: the insertion of a cytosine at nucleotide position 640 (AF073308.1:_c.640insC, AAC69324.1:_p. Thr215HisfsX8) which does not lead to hearing impairment PMID: 17427029
    18. GCs induce dfna5 mRNA and its expression appears to be repressed in the basal state. Induction of dfna5 mRNA correlates with GC-dependent apoptosis of CEM cells, though dfna5 expression alone is not sufficient for apoptosis. PMID: 17616391
    19. DFNA5-associated hearing loss is caused by a very specific gain-of-function mutation. PMID: 17868390
    20. DFNA5 is a novel tumor suppressor gene in CRC and a valuable molecular marker for human cancer PMID: 18223688
    21. These data implicate DFNA5 promoter methylation as a novel molecular biomarker in human breast cancer. PMID: 18346456

    收起更多

  • 相关疾病：
    Deafness, autosomal dominant, 5 (DFNA5)
  • 亚细胞定位：
    [Gasdermin-E, N-terminal]: Cell membrane; Multi-pass membrane protein.; [Gasdermin-E]: Cytoplasm, cytosol.
  • 蛋白家族：
    Gasdermin family
  • 组织特异性：
    Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.
  • 数据库链接：

    HGNC: 2810

    OMIM: 600994

    KEGG: hsa:1687

    STRING: 9606.ENSP00000339587

    UniGene: Hs.520708

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