HLA-DOB Antibody

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) HLA-DOB Polyclonal antibody
Uniprot No.：

P13765
基因名：

HLA-DOB
宿主：

Rabbit
反应种属：

Human
免疫原：

Synthesized peptide derived from N-terminal of Human HLA-DOB.
免疫原种属：

Homo sapiens (Human)
克隆类型：

Polyclonal
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
产品提供形式：

Liquid
应用范围：

ELISA,WB

推荐稀释比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
基因功能参考文献：
1. results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID: 28813660
2. HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID: 23400868
3. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID: 15730525
亚细胞定位：

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
蛋白家族：

MHC class II family
数据库链接：

HGNC: 4937

OMIM: 142920

KEGG: hsa:3112

STRING: 9606.ENSP00000390020

UniGene: Hs.1802