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  4. HLA-DRB3 Antibody, FITC conjugated

HLA-DRB3 Antibody, FITC conjugated

说明书
  • 中文名称：
    HLA-DRB3兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA302920LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HLA-DRB3 Polyclonal antibody
  • Uniprot No.：
    P79483
  • 基因名：
    HLA-DRB3
  • 别名：
    DR beta 3 chain antibody; DR7 antibody; DRB3_HUMAN antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DR beta 3 chain antibody; HLA class II histocompatibility antigen DRB1 7 beta chain antibody; HLA DR3B antibody; HLA-DRB3 antibody; Human leucocyte antigen DRB3 antibody; Major histocompatibility complex class II DR beta 3 antibody; MGC117330 antibody; MHC class II antigen DR beta 3 chain antibody; MHC class II antigen DRB3 antibody; MHC class II HLA DR beta 3 chain antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human HLA class II histocompatibility antigen, DR beta 3 chain protein (111-227AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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HLA-DRB3 antibodies

HLA-DRB3 Proteins

靶点详情

  • 功能：
    A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise ...显示更多
  • 基因功能参考文献：
    1. In contrast to HLA-DRB4*01:01P, the inheritance of HLA-DRB3*01:01 is strongly associated with the propensity for mounting a humoral immune response against fetal HPA-1a antigen. PMID: 28019029
    2. The first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese. PMID: 27181214
    3. HLA-DRB3 affects type 1 diabetes risk and islet autoantibodies. PMID: 26740600
    4. this mouse model unravels a critical role for HLA-DR3 in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background. PMID: 26475924
    5. Haplotyping was done on 91 Southern Europe celiac patients. HLA-DR3-DQ2 without HLA-DR7-DQ2 was present in 62.6%, HLA-DR7-DQ2 without HLA-DR3-DQ2 was present in 16.5% and HLA-DR4-DQ8 without HLA-DQ2 was present in 3.3%. PMID: 24628273
    6. Children with the HLA haplotype DR3-DQ2, especially homozygotes, were found to be at high risk for celiac disease autoimmunity and celiac disease early in childhood. PMID: 24988556
    7. HLA-DRB3*02:02 on the DRB1*03:01 haplotype can contribute to type 1 diabetes risk. PMID: 23462545
    8. Three sets of HLA-DR3-positive haplotypes are designed that provide maximum risk of type 1 diabetes development in Indians and suggest a common Caucasian ancestor from which multiple haplotypes evolve independently. PMID: 23387390
    9. Heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia. PMID: 22671039
    10. There was a strong sporadic inclusion body myositis association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. PMID: 23010279
    11. TNF associations with type 1 diabetes are caused by their linkage disequilibrium with specific HLA-DR3-DQ2 haplotypes in the Indian population. PMID: 22366579
    12. In addition to confirming one of the top findings in the meta-analysis, TRIM26, RNF5 and HLA-DRB3 have been identified as potential candidate genes for schizophrenia. PMID: 22433715
    13. There are no significant differences in the HLA-DRB3/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults. PMID: 22531795
    14. All patients with sporadic inclusion body myositis carried the HLA-DRB1*0301 allele, or its equivalent HLA-DR3 serological specificity PMID: 21507567
    15. IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4. PMID: 20371654
    16. results suggest that DRB3 plays a significant role in antigen presentation with different epitopic preferences to DRB1. PMID: 19830726
    17. HLA-DR3 is associated with anti-cyclic citrullinated peptide antibody-negative arthritis and not with anti-CCP-positive arthritis PMID: 16200610
    18. HLA-DR3 alleles are associated with anti-CCP- disease and with lower levels of anti-CCP antibodies PMID: 16320316
    19. The HLA-DR locus seems to be associated with the genetic susceptibility to develop SNP in Mexicans. PMID: 16815190
    20. very pronounced distribution bias (P<10(-5)) of the two major DR3 conserved extended haplotypes, with DR3-B18 predominating in type 1 diabetes and DR3-B8 in celiac disease PMID: 16929349
    21. German patients were distinct from Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2 HLA in autoimmune hepatitis (AIH) type 1. PMID: 17006990
    22. HLA-DR and INS VNTR alleles mark both type 1 diabetes disease susceptibility and separate Caucasian parental subpopulations PMID: 17052889
    23. DR3 is strongly associated with ulcerative colitis protection in a Spanish population. PMID: 17714554
    24. The researchers found an association between HLA-DR3 and the presence of anti-Ro/La antibodies in patients with SLE. PMID: 17910142
    25. No particular HLA-DR and DQ alleles, as well as tumor necrosis factor alpha and CTLA-4 genotypes, were associated with CAID. PMID: 18223493
    26. HLA-DR3 allele may influence susceptibility to the sporadic inclusion body myositis. PMID: 18258695
    27. Risk of type I diabetes in individuals with extended DR3 haplotype 8.1 is genotype-dependent, possibly associated with DPB1 and HLA class I loci. PMID: 18486765
    28. T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells PMID: 19136661
    29. This study showed that significant expression of HLA-DRB3 genotypes in patients with human high-grade gliomas in Sicily. PMID: 19487887
    30. interactions between Tg and discrete HLA-DR pocket signatures contribute to the initiation of autoimmune thyroid disease PMID: 19776016

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Autolysosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    MHC class II family
  • 组织特异性：
    Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level).
  • 数据库链接：

    HGNC: 4951

    OMIM: 612735

    KEGG: hsa:3125

    UniGene: Hs.696211

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