INPP5F Antibody, HRP conjugated
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中文名称：
INPP5F兔多克隆抗体, HRP偶联
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货号：
CSB-PA896692NB01HU
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规格：
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其他：
产品详情
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产品名称：
Rabbit anti-Homo sapiens (Human) INPP5F Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：
INPP5F antibody; KIAA0966 antibody; SAC2 antibody; MSTP007 antibody; MSTP047 antibody; Phosphatidylinositide phosphatase SAC2 antibody; EC 3.1.3.25 antibody; Inositol polyphosphate 5-phosphatase F antibody; Sac domain-containing inositol phosphatase 2 antibody; Sac domain-containing phosphoinositide 4-phosphatase 2 antibody; hSAC2 antibody
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宿主：
Rabbit
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反应种属：
Human
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免疫原：
Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA)
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免疫原种属：
Homo sapiens (Human)
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标记方式：
HRP
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克隆类型：
Polyclonal
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抗体亚型：
IgG
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纯化方式：
>95%, Protein G purified
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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产品提供形式：
Liquid
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应用范围：
ELISA
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway thro...
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基因功能参考文献：
- we identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival in Chronic lymphocytic leukemia PMID: 26430724
- These findings suggest that INPP5F is a potential tumor suppressor in gliomas via inhibition of STAT3 pathway, and that deregulation of INPP5F may lead to contribution to gliomagenesis. PMID: 25476455
- Sac2 colocalizes with early endosomal markers and is recruited to transferrin-containing vesicles during endocytic recycling. PMID: 25869669
- Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. PMID: 19875726
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亚细胞定位：
Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
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组织特异性：
Ubiquitous. Highly expressed in brain.
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数据库链接：
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