INTS11 Antibody

文献引用 (1) 说明书

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) INTS11 Polyclonal antibody
Uniprot No.：

Q5TA45
基因名：

INTS11
别名：

2410006F12Rik antibody; AU044035 antibody; Cleavage and polyadenylation specific factor 3 like antibody; Cleavage and polyadenylation-specific factor 3-like protein antibody; CPSF3 like protein antibody; CPSF3-like protein antibody; CPSF3L antibody; CPSF73L antibody; FLJ13294 antibody; FLJ20542 antibody; Human integrator complex subunit 11 antibody; INT 11 antibody; Int11 antibody; INT11_HUMAN antibody; Integrator complex subunit 11 antibody; INTS 11 antibody; INTS11 antibody; MGC124975 antibody; OTTHUMP00000044092 antibody; Protein related to CPSF subunits of 68 kDa antibody; RC 68 antibody; RC 68, related antibody; RC-68 antibody; RC68 antibody; Related to CPSF subunits 68 kDa antibody; Related to CPSF subunits, 68 kDa protein antibody; RGD1306841 antibody; RP23 242K15.19 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Integrator complex subunit 11 protein (331-600AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产品提供形式：

Liquid
应用范围：

ELISA, WB, IHC

推荐稀释比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
基因功能参考文献：
1. Functional studies demonstrate that the IntS9-IntS11 interaction is crucial for the role of INT in snRNA 3'-end processing. PMID: 28396433
2. The specific heterodimeric interaction between IntS9 and IntS11 is mediated by a discrete domain present at the extreme C terminus of IntS9 and within the C terminus of IntS11, adjacent to the predicted active site of this endonuclease. PMID: 22252320
亚细胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS11 subfamily
数据库链接：

HGNC: 26052

OMIM: 611354

KEGG: hsa:54973

STRING: 9606.ENSP00000413493

UniGene: Hs.6449