IPPK Antibody

产品详情

Uniprot No.：

Q9H8X2
基因名：

IPPK
别名：

3 antibody; 4 antibody; 5 antibody; 6)P5 2-kinase antibody; 6-pentakisphosphate 2-kinase antibody; bA476B13.1 (novel protein) antibody; bA476B13.1 antibody; C9orf12 antibody; inositol 1,3,4,5,6 pentakisphosphate 2 kinase antibody; Inositol pentakisphosphate 2 kinase antibody; Inositol-1 antibody; Inositol-pentakisphosphate 2-kinase antibody; Ins antibody; Ins(1 antibody; Ins(1,3,4,5,6)P5 2 kinase antibody; InsP5 2 kinase antibody; InsP5 2-kinase antibody; INSP5K2 antibody; IP5K antibody; IPK1 antibody; IPK1 homolog antibody; IPPK antibody; IPPK_HUMAN antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human InsP5 2-kinase.
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
产品提供形式：

Liquid
应用范围：

WB, IHC, IF, ELISA

推荐稀释比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
基因功能参考文献：
1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
2. IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. PMID: 26976604
3. IPK1 substrate selection is linked to the ability of each potential substrate to stabilize IPK1. PMID: 24165122
4. identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme PMID: 12084730
亚细胞定位：

Cytoplasm. Nucleus.
蛋白家族：

IPK1 type 2 family
组织特异性：

Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
数据库链接：

HGNC: 14645

KEGG: hsa:64768

STRING: 9606.ENSP00000287996

UniGene: Hs.459896