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  4. ITPK1 Antibody

ITPK1 Antibody

说明书
  • 中文名称：
    ITPK1兔多克隆抗体
  • 货号：
    CSB-PA011278
  • 规格：
    ￥1090
  • 其他：

产品详情

  • Uniprot No.：
    Q13572
  • 基因名：
    ITPK1
  • 别名：
    3 antibody; 4)P(3) 5/6-kinase antibody; 4-trisphosphate 5/6-kinase antibody; Inositol 1 3 4 triphosphate 5/6 kinase antibody; Inositol 1 3 4 trisphosphate 5/6 kinase antibody; Inositol 1 antibody; Inositol tetrakisphosphate 1 kinase antibody; Inositol triphosphate 5/6 kinase antibody; Inositol-tetrakisphosphate 1-kinase antibody; Inositol-triphosphate 5/6-kinase antibody; Ins(1 3 4)P(3) 5/6 kinase antibody; Ins(1 antibody; ITPK 1 antibody; itpk1 antibody; ITPK1_HUMAN antibody; ITRPK 1 antibody; ITRPK1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ITPK1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
    Western Blotting (WB) Protocol
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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ITPK1 antibodies

ITPK1 Proteins

靶点详情

  • 功能：
    Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4...显示更多
  • 基因功能参考文献：
    1. The results suggested that the maternal rs3783903 of ITPK1 might be associated with spina bifida, and the allele G of rs3783903 might affect the binding of AP-1 and the decrease of maternal plasma inositol hexakisphosphate concentration. PMID: 24465924
    2. Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1. PMID: 22928859
    3. HEK293 cells stably expressing acetylated ITPK1 had reduced levels of the higher phosphorylated forms of inositol, compared with the levels seen in cells expressing unacetylated ITPK1 PMID: 22308441
    4. 5/6-kinase modifies TNFalpha-induced apoptosis by interfering with the activation of TNF-R1-associated death domain PMID: 12925536
    5. analysis of inositol phosphate signaling pathway integration via human ITPK1 PMID: 17616525

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  • 蛋白家族：
    ITPK1 family
  • 组织特异性：
    Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.
  • 数据库链接：

    HGNC: 6177

    OMIM: 601838

    KEGG: hsa:3705

    STRING: 9606.ENSP00000267615

    UniGene: Hs.308122

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