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  4. KLRD1 Antibody, Biotin conjugated

KLRD1 Antibody, Biotin conjugated

说明书
  • 中文名称：
    KLRD1兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA615672LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KLRD1 Polyclonal antibody
  • Uniprot No.：
    Q13241
  • 基因名：
    KLRD1
  • 别名：
    CD 94 antibody; CD94 antibody; CD94 antigen antibody; Killer cell lectin like receptor subfamily D member 1 antibody; Killer cell lectin-like receptor subfamily D member 1 antibody; KLRD 1 antibody; KLRD1 antibody; KLRD1 protein antibody; KLRD1_HUMAN antibody; KP 43 antibody; KP43 antibody; Natural killer cells antigen CD94 antibody; NK cell receptor antibody; OTTHUMP00000238754 antibody; OTTHUMP00000238755 antibody; OTTHUMP00000238756 antibody; OTTHUMP00000238758 antibody; OTTHUMP00000239093 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Natural killer cells antigen CD94 protein (42-168AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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KLRD1 antibodies

KLRD1 Proteins

靶点详情

  • 功能：
    Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.; KLRD1-KLRC1 acts as an immune inhibitory rece...显示更多
  • 基因功能参考文献：
    1. an early response by KLRD1-expressing Natural killer cells may control influenza infection. PMID: 29898768
    2. it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells. PMID: 24975965
    3. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PMID: 24082146
    4. Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function. PMID: 22576308
    5. Loss of CD94 is associated with rheumatoid arthritis. PMID: 22102879
    6. increased expression on natural killer cells in women with recurrent spontaneous abortion after IVIG therapy PMID: 19811464
    7. human CD56(bright) NK cells progress through a continuum of differentiation that ends with a CD94(low)CD56(dim) phenotype. PMID: 19897577
    8. Conservation and variation in human and chimpanzee CD94 genes PMID: 11751968
    9. A critical role of CD94-dependent MHC-I recognition for the regulation of IFN-gamma production and target lysis was demonstrated. PMID: 12149421
    10. TCR specificity dictates CD94/NKG2A expression by CTL. PMID: 12387742
    11. CD94 gene expression is regulated by distal and proximal promoters that transcribe unique initial exons specific to each promoter, resulting in two species of transcripts--the previously described CD94 mRNA and a novel CD94C mRNA. PMID: 14607929
    12. Aberrant expression of natural killer (NK) receptors CD94/NKG2A may have an impact on the magnitude and direction of dendritic cell activation of T cells under pathological conditions, such as chronic hepatitis C virus infection. PMID: 15528343
    13. A CD94 alternatively spliced transcript paired with an NKG2B isoform may contribute to the plasticity of the natural killer cell immunological synapse by insuring an adequate inhibitory signal. PMID: 16237464
    14. Cytolytic activity levels of purified CD94-expressing cells from 7-day cultures with FK506 were much higher than those from 7-day cultures without FK506. PMID: 16378079
    15. results indicate that the SNPs of the inhibitory receptor CD94/NKG2A and its haplotypes, as well as its ligand HLA-E, are associated with Behcet's disease immune systems PMID: 17767552
    16. identified molecular characteristics of an aggressive subset of pediatric patients with AML through a prospective evaluation of CD56+ neural cell adhesion molecule (NCAM) and CD94 expression PMID: 18323797
    17. Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor is described. PMID: 18363778
    18. Under the influence of interleukin-12 stimulation, CD94/NKG2A is transiently inducible in natural killer (NK) cells bearing the homologous CD94/NKG2C-activating receptor, providing a potential negative regulatory feedback mechanism. PMID: 19124726
    19. In this work, the glycan ligands of NKG2D and CD94 for the first time were resolved. PMID: 19303396
    20. NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides. PMID: 19555665

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed in NK cell subsets (at protein level). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level). Expressed in melanoma-specific cytotoxic T cell clones (at protein level). Expressed in terminally differentiated cyto
  • 数据库链接：

    HGNC: 6378

    OMIM: 602894

    KEGG: hsa:3824

    STRING: 9606.ENSP00000338130

    UniGene: Hs.562457

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