LRRC8D Antibody

产品详情

Uniprot No.：

Q7L1W4
基因名：

LRRC8D
别名：

LRRC8D antibody; LRRC5 antibody; UNQ213/PRO239 antibody; Volume-regulated anion channel subunit LRRC8D antibody; Leucine-rich repeat-containing protein 5 antibody; Leucine-rich repeat-containing protein 8D antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Human LRRC8D
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, ...显示更多
基因功能参考文献：
1. LRRC8D is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
2. identified four genes, named TA-LRRP, AD158, LRRC5, and FLJ23420, as unknown LRRC8-like genes PMID: 15094057
亚细胞定位：

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

LRRC8 family
数据库链接：

HGNC: 16992

OMIM: 612890

KEGG: hsa:55144

STRING: 9606.ENSP00000338887

UniGene: Hs.482087