MAP3K6 Antibody

中文名称：

MAP3K6兔多克隆抗体
货号：

CSB-PA013428LA01HU
规格：

￥440
图片：
IHC image of CSB-PA013428LA01HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with CSB-PA013428LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) MAP3K6 Polyclonal antibody
Uniprot No.：

O95382
基因名：

MAP3K6
别名：

Apoptosis signal regulating kinase 2 antibody; Apoptosis signal-regulating kinase 2 antibody; ASK2 antibody; EC 2.7.11.25 antibody; M3K6_HUMAN antibody; MAP3K6 antibody; MAPKKK6 antibody; MEKK6 antibody; MGC125653 antibody; MGC20114 antibody; Mitogen-activated protein kinase kinase kinase 6 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Mitogen-activated protein kinase kinase kinase 6 protein (905-990AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，MAP3K6 Antibody (CSB-PA013428LA01HU)，的标记方式是Non-conjugated。对于MAP3K6 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA013428LB01HU	MAP3K6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013428LC01HU	MAP3K6 Antibody, FITC conjugated
Biotin	CSB-PA013428LD01HU	MAP3K6 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC, IF

推荐稀释比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
基因功能参考文献：
1. Data show that the MAPKKK6 ASK2, a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB) expression. PMID: 26243192
2. MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for familial gastric cancer PMID: 25340522
3. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. PMID: 17210579
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
数据库链接：

HGNC: 6858

OMIM: 604468

KEGG: hsa:9064

STRING: 9606.ENSP00000350195

UniGene: Hs.194694