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中文名称：
MAPK4兔多克隆抗体
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货号：
CSB-PA013457ESR1HU
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规格：
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图片：
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Western blot
All lanes: MAPK4 ntibody at 6μg/ml
Lane 1: Mouse brain tissue
Lane 2: 293T whole cell lysate
Lane 3: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa
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Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013457ESR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA013457ESR1HU at dilution of 1:100
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其他：
产品详情
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产品名称：
Rabbit anti-Homo sapiens (Human) MAPK4 Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：
ERK-4 antibody; ERK3 antibody; Erk3 related antibody; ERK4 antibody; Extracellular signal regulated kinase 4 antibody; Extracellular signal-regulated kinase 4 antibody; MAP kinase 4 antibody; MAP kinase isoform p63 antibody; MAPK 4 antibody; MAPK4 antibody; Mitogen activated protein kinase 4 antibody; Mitogen-activated protein kinase 4 antibody; MK04_HUMAN antibody; p63 MAPK antibody; p63-MAPK antibody; p63MAPK antibody; PRKM4 antibody; Protein kinase; mitogen-activated; 4 antibody; Protein-tyrosine kinase ERK3-related antibody; RMNK2 antibody
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宿主：
Rabbit
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反应种属：
Human, Mouse
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免疫原：
Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA)
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免疫原种属：
Homo sapiens (Human)
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标记方式：
Non-conjugated
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克隆类型：
Polyclonal
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抗体亚型：
IgG
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纯化方式：
Antigen Affinity Purified
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式：
Liquid
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应用范围：
ELISA, WB, IHC
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推荐稀释比：
| Application |
Recommended Dilution |
| WB |
1:500-1:2000 |
| IHC |
1:20-1:200 |
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.
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基因功能参考文献：
- Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. PMID: 21177870
- Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5. PMID: 19473979
- Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3. PMID: 16973613
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亚细胞定位：
Cytoplasm. Nucleus.
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蛋白家族：
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
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组织特异性：
High expression in heart and brain.
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数据库链接：
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