MRGPRX1 Antibody

中文名称：

MRGPRX1兔多克隆抗体
货号：

CSB-PA290385
规格：

￥1100
图片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

产品详情

Uniprot No.：

Q96LB2
基因名：

MRGPRX1
别名：

MRGPRX1; MRGX1; SNSR3; SNSR4; Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4
宿主：

Rabbit
反应种属：

Human
免疫原：

Synthetic peptide of Human MRGPRX1
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

Antigen affinity purification
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
产品提供形式：

Liquid
应用范围：

ELISA,IHC

推荐稀释比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a h...显示更多
基因功能参考文献：
1. MRGPRX1 is a promising target for pain inhibition, a humanized mouse model expressing this receptor has been described. PMID: 28223516
2. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. PMID: 28768771
3. analysis of the functional interactions between MRGPR-X1 and TRPV1 PMID: 23074220
亚细胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Mas subfamily
组织特异性：

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
数据库链接：

HGNC: 17962

OMIM: 607227

KEGG: hsa:259249

STRING: 9606.ENSP00000305766

UniGene: Hs.711459