MYLK2 Antibody

产品详情

Uniprot No.：

Q9H1R3
基因名：

MYLK2
别名：

KMLC antibody; MLCK antibody; MLCK, skeletal/cardiac antibody; MLCK2 antibody; MYLK 2 antibody; MYLK2 antibody; MYLK2_HUMAN antibody; Myosin light chain kinase 2 antibody; Myosin light chain kinase 2 skeletal muscle antibody; Myosin light chain kinase 2 skeletal/cardiac muscle antibody; MYOSIN LIGHT POLYPEPTIDE KINASE antibody; Myosin light polypeptide kinase, skeletal/cardiac antibody; Skeletal muscle myosin light chain kinase antibody; Skeletal myosin light chain kinase antibody; skeletal/cardiac muscle antibody; skMLCK antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Human MYLK2
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
基因功能参考文献：
1. the P2X1-ERK2-Myosin Light Chain Kinase axis contributes to collagen-induced platelet activation by enhancing platelet degranulation PMID: 14500714
2. These data suggest that the kinase domain of MYLK2 is rarely mutated in common human carcinomas and that it does not play a dominant role in cancer pathogenesis. PMID: 16448786
3. MYLK gene is a risk factor for the development of acute lung injuries. PMID: 18828194
4. Data show that that the prototypical CaM target sequence skMLCK, a fragment from skeletal muscle myosin light chain kinase, binds to CaM in a highly cooperative way, while only a lower degree of interdomain binding cooperativity emerges for CaMKK. PMID: 19667195
相关疾病：

Cardiomyopathy, familial hypertrophic (CMH)
亚细胞定位：

Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family
组织特异性：

Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
数据库链接：

HGNC: 16243

OMIM: 192600

KEGG: hsa:85366

STRING: 9606.ENSP00000365152

UniGene: Hs.86092