OPN3 Antibody, Biotin conjugated
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中文名称：OPN3兔多克隆抗体, Biotin偶联
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货号：CSB-PA872435LD01HU
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规格：￥880
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其他：
产品详情
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产品名称：Rabbit anti-Homo sapiens (Human) OPN3 Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：OPN3; ECPN; Opsin-3; Encephalopsin; Panopsin
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宿主：Rabbit
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反应种属：Human
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免疫原：Recombinant Human Opsin-3 protein (313-402AA)
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免疫原种属：Homo sapiens (Human)
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标记方式：Biotin
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克隆类型：Polyclonal
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抗体亚型：IgG
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纯化方式：>95%, Protein G purified
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浓度：It differs from different batches. Please contact us to confirm it.
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保存缓冲液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式：Liquid
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应用范围：ELISA
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Protocols：
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储存条件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶点详情
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功能：G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin. Binds both 11-cis retinal and all-trans retinal. Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light. Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling. Additionally regulates apopto...显示更多
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基因功能参考文献：
- Decreased OPN3 levels in Bel7402(5-FU) cells activated the anti-apoptotic pathway through increasing phospho-Akt and the Bcl2/Bax ratio, while overexpression of OPN3 inactivated this pathway. PMID: 22313545
- Assignment of panopsin (OPN3) to human chromosome band 1q43 PMID: 12063405
- Human OPN3 gene consists of six exons and expresses various splice variants. PMID: 12242008
- Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma. PMID: 18344558
- Related persons with heterozygous germline deletions of 1q42.3, which includes EXO1, RGS7, KMO, CHML, and OPN3, showed no phenotypic abnormalities other than multiple leiomyomatosis. PMID: 14623461
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亚细胞定位：Cell membrane; Multi-pass membrane protein. Cytoplasm.
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蛋白家族：G-protein coupled receptor 1 family, Opsin subfamily
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组织特异性：Expressed in tracheal airway smooth muscle (at protein level). Expressed throughout the epidermis and dermis, predominantly in the basal layer on the facial and abdominal skin (at protein level). Expressed in dermal fibroblasts (at protein level). Express
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