PFKL Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) PFKL Polyclonal antibody
Uniprot No.：

P17858
基因名：

PFKL
别名：

PFKL antibody; ATP-dependent 6-phosphofructokinase antibody; liver type antibody; ATP-PFK antibody; PFK-L antibody; EC 2.7.1.11 antibody; 6-phosphofructokinase type B antibody; Phosphofructo-1-kinase isozyme B antibody; PFK-B antibody; Phosphohexokinase antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human ATP-dependent 6-phosphofructokinase, liver type protein (229-479AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
基因功能参考文献：
1. Liver PFK1 isoform assembles into filaments in a tetramer- and substrate-dependent manner,organizing isoform specific glucose metabolism in cells. PMID: 28646105
2. findings showed glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells PMID: 22923583
亚细胞定位：

Cytoplasm.
蛋白家族：

Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade "E" sub-subfamily
数据库链接：

HGNC: 8876

OMIM: 171860

KEGG: hsa:5211

STRING: 9606.ENSP00000269848

UniGene: Hs.255093