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中文名称：
PRKACG兔多克隆抗体
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货号：
CSB-PA942370
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规格：
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图片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA942370(PRKACG Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA942370(PRKACG Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
产品详情
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Uniprot No.：
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基因名：
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别名：
cAMP-dependent protein kinase catalytic subunit gamma antibody; KAPCG_HUMAN antibody; KAPG antibody; PKA C gamma antibody; PKA C-gamma antibody; PKACg antibody; PRKACG antibody; Protein kinase cAMP dependent catalytic gamma antibody; Serine (threonine) protein kinase antibody
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宿主：
Rabbit
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反应种属：
Human
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免疫原：
Fusion protein of Human PRKACG
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免疫原种属：
Homo sapiens (Human)
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标记方式：
Non-conjugated
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抗体亚型：
IgG
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纯化方式：
Antigen affinity purification
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式：
Liquid
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应用范围：
ELISA,IHC
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推荐稀释比：
| Application |
Recommended Dilution |
| ELISA |
1:2000-1:5000 |
| IHC |
1:25-1:100 |
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
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基因功能参考文献：
- The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A in megakaryocytes. PMID: 25061177
- PKA-mediated phosphorylation of GPIbbeta at Ser(166) negatively regulates VWF binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition PMID: 12361948
- Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation. PMID: 15039079
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相关疾病：
Bleeding disorder, platelet-type 19 (BDPLT19)
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蛋白家族：
Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
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组织特异性：
Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.
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数据库链接：
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