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  4. PRKAG1 Antibody, FITC conjugated

PRKAG1 Antibody, FITC conjugated

说明书
  • 中文名称：
    PRKAG1兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA01149C0Rb
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRKAG1 Polyclonal antibody
  • Uniprot No.：
    P54619
  • 基因名：
    PRKAG1
  • 别名：
    5' AMP activated protein kinase gamma 1 subunit antibody; 5' AMP activated protein kinase subunit gamma 1 antibody; 5''-AMP-activated protein kinase subunit gamma-1 antibody; AAKG1_HUMAN antibody; AMP activated protein kinase noncatalytic gamma 1 subunit antibody; AMPK gamma 1 chain antibody; AMPK gamma1 antibody; AMPK subunit gamma-1 antibody; AMPKg antibody; MGC8666 antibody; PRKAG 1 antibody; PRKAG1 antibody; Protein kinase AMP activated gamma 1 non catalytic subunit antibody; protein kinase; AMP-activated; noncatalytic gamma-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 5'-AMP-activated protein kinase subunit gamma-1 protein (1-331AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PRKAG1 antibodies

靶点详情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling...显示更多
  • 基因功能参考文献：
    1. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
    2. Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK PMID: 26276391
    3. Letter: report PRKAG1 frameshift mutations in colorectal cancer. PMID: 25267969
    4. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). PMID: 24356547
    5. PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. PMID: 23479427
    6. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. PMID: 22456184
    7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. PMID: 19052260

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  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 数据库链接：

    HGNC: 9385

    OMIM: 602742

    KEGG: hsa:5571

    STRING: 9606.ENSP00000323867

    UniGene: Hs.530862

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