RORA Antibody, Biotin conjugated

1. three copy-number variant deletions (two de novo and one dominantly inherited in three generations), one de novo disrupting duplication, and nine de novo point mutations (three truncating, one canonical splice site, and five missense mutations) involving RORA, are reported. PMID: 29656859
2. We have identified RORalpha as a regulator of Treg genes responsible for suppressing allergic skin inflammation and also documented higher expression of RORalpha in skin-resident Tregs than in peripheral blood circulating Tregs in humans, suggesting that RORalpha and the TL1A-DR3 circuit could be therapeutically targeted in atopic dermatitis. PMID: 29500225
3. RORA downregulation may be a potential indicator of positive response to interferon beta treatment of multiple sclerosis patients PMID: 29889063
4. In the present study we have detected an association between rs4774388 genotype and breast cancer risk in a population of Iranian breast cancer patients. PMID: 28598825
5. rs4774388-TT genotype was significantly higher in patients compared with controls and was associated with autism spectrum disorder risk in dominant inheritance model PMID: 28608249
6. human melanoma development and aggressiveness is associated with decreased expression of RORalpha and RORgamma, suggesting that RORs could be important in melanoma progression and host responses against the tumor PMID: 27542227
7. CYP11A1- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma. PMID: 27693422
8. The expression RORalpha is significantly elevated under hypoxic conditions in keratinocytes in an HIF-1alpha dependent manner. PMID: 28332183
9. RORgammat and RORalpha have overlapping roles in human Th17 cell differentiation through regulation of a defined common set of Th17 genes PMID: 28763457
10. Retinoid-related orphan receptor alpha-regulated development of the mouse cerebellum has a distinct critical period for (1) lengthening Purkinje cell (PC) primary dendrite stems and the eventual increase in the thickness of the molecular layer and (2) the establishment of mGluR signaling and associated removal of surplus climbing fibers from PCs. PMID: 26122696
11. findings strongly suggest that CLDND1 is a direct RORalpha target PMID: 28130419
12. TRIB3 promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha and inhibition of p53-mediated senescence. PMID: 28486108
13. the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha gene (PPARGC1A or PGC-1alpha) were significantly associated with the Li response. Our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A and RORA involved in circadian rhythms and bioenergetics processes in Li response PMID: 27324142
14. The present study is to determine if any relation exists between RORA rs11639084 and rs4774388 gene polymorphisms on the individual susceptibility of multiple sclerosis. PMID: 27653902
15. ROR-alpha may regulate signaling receptor activity, and transmembrane transport activity through its potential target genes. PMID: 28238834
16. Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China. PMID: 28262136
17. this animal model study suggests that the NR, RORalpha4, has a critical regulatory role in the phenotype associated with decreased subcutaneous fat deposition, fatty liver and impaired glucose tolerance. PMID: 27568222
18. The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults. PMID: 25892098
19. A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of placental abruption. PMID: 26515929
20. status epilepticus induced by pilocarpine is able to change the expression and daily variation of RORalpha in the rat hippocampal area during the acute and silent phases PMID: 26731717
21. In a Han Chinese population, an association between RORA gene variation and depression personality trait was found. PMID: 26184991
22. associations between NR1D1, RORA and RORB genes and bipolar disorder.( PMID: 25789810
23. Retinoid-related orphan receptor alpha has gained attention as a new candidate in stress-related disorders, especially depression. PMID: 25826113
24. Identify RORalpha as being essential to drive inflammation in experimental epidermolysis bullosa acquisita. PMID: 25953430
25. the data presented in this report are that RORA is linked in important ways to molecules that could be playing important roles in the AD etiology. PMID: 25362032
26. Retinoic acid receptor-related orphan receptor-alpha (RORalpha) may be a potential risk gene for chronic obstructive pulmonary disease (COPD). PMID: 24943193
27. RORA variants were associated with dyslipidemia and obesity in Mexicans. PMID: 24886709
28. RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians. PMID: 25668517
29. A cluster of RORA SNPs around rs2083074 showed an effect on psychic adverse drug reactions in the bipolar disorder. PMID: 25129258
30. This information suggests that RORalpha is a potent tumor suppressor and a potential therapeutic target for breast cancer. PMID: 23443091
31. RORalpha and its target gene expressions are lower in colorectal tumor tissue compared with control colorectal tissue. PMID: 25500738
32. RORalpha mediates reprogramming of glucose metabolism in hepatoma cells in response to glutamine deficiency. PMID: 25346526
33. TIMELESS and RORA genes may confer susceptibility to bipolar disorders and impact on circadian phenotypes PMID: 24716566
34. Two single nucleotide polymorphisms in RORA were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA, and NPAS2 in the analyses at the gene level PMID: 24919398
35. down-regulated RORalpha expression was associated with poorer prognosis in HCC patients. PMID: 24798975
36. Data indicate that intellectual disability and epilepsy are frequently observed with 15q22.2 deletions including the NMDA receptor-regulated 2 gene (NARG2) and the PAR-related orphan receptor A gene (RORA). PMID: 24525055
37. These results reveal a novel link between ROR-alpha and E2F1 in regulating cell cycle progression and mammary tissue morphogenesis. PMID: 24891616
38. 20(OH)D3 and 20,23(OH)2D3 act as antagonists or inverse agonists of RORalpha and RORgamma. PMID: 24668754
39. The retinoid-related orphan receptor RORalpha promotes keratinocyte differentiation via FOXN1. PMID: 23922987
40. RORA genotype predicted circadian rhythm period lengthening by lithium, specifically among bipolar disorder cases. PMID: 24150227
41. DSG1, DSG3 and RORA values of the study group were not statistically different from control group (p > 0.05). PMID: 24142618
42. found an association at genome-wide levels of significance between PTSD and the retinoic acid orphan receptor alpha. receptor A (RORA) gene PMID: 22869035
43. Deficiency of RORalpha caused a damped transcriptional oscillation of Npas2 in NIH 3T3 cells. PMID: 24196956
44. RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels. PMID: 24226095
45. this study reveals a novel RORalpha-dependent escape mechanism by which H5N1 prevents an effective inflammatory response of monocytes blocking NF-kappaB-dependent gene expression. PMID: 23445660
46. RORA SNPs are associated with childhood asthma and show epistasis with NPSR1, and the interaction between RORA and NPSR1 may be of biological relevance. PMID: 23565190
47. RORA expression was downregulated in colorectal adenocarcinomas compared to normal controls and correlated with time to disease progression PMID: 22104449
48. SULT2A1 as a novel ROR-alpha and ROR-gamma target gene. PMID: 23211525
49. the results of this study indicate that cholesterol sulfate induces filaggrin expression through increased RORalpha expression. PMID: 23063684
50. Genetic variants of RORA associate with depressive disorder and bipolar disorder. PMID: 22538398

显示更多

收起更多

HGNC: 10258

OMIM: 600825

KEGG: hsa:6095

STRING: 9606.ENSP00000261523

UniGene: Hs.560343