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中文名称：
RPA4兔多克隆抗体
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货号：
CSB-PA622640ESR2HU
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规格：
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图片：
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Western blot
All lanes: RPA4 antibody at 3μg/ml
Lane 1: K562 whole cell lysate
Lane 2: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 29 kDa
Observed band size: 29 kDa
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA622640ESR2HU at dilution of 1:100
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其他：
产品详情
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产品名称：
Rabbit anti-Homo sapiens (Human) RPA4 Polyclonal antibody
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Uniprot No.：
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基因名：
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别名：
HSU24186 antibody; MGC120333 antibody; MGC120334 antibody; p30 antibody; Replication factor A protein 4 antibody; Replication protein A 30 kDa subunit antibody; RF A antibody; RF-A protein 4 antibody; RFA antibody; RFA4_HUMAN antibody; RP A antibody; RP-A p30 antibody; RPA antibody; RPA4 antibody
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宿主：
Rabbit
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反应种属：
Human, Mouse
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免疫原：
Recombinant Human Replication protein A 30 kDa subunit protein (1-230AA)
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免疫原种属：
Homo sapiens (Human)
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标记方式：
Non-conjugated
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克隆类型：
Polyclonal
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抗体亚型：
IgG
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纯化方式：
Antigen Affinity Purified
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式：
Liquid
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应用范围：
ELISA, WB, IHC
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推荐稀释比：
| Application |
Recommended Dilution |
| WB |
1:200-1:1000 |
| IHC |
1:20-1:200 |
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
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基因功能参考文献：
- Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells. PMID: 19996105
- Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell. PMID: 19942684
- Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage. PMID: 15929725
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亚细胞定位：
Nucleus. Note=Localizes to DNA repair foci after DNA damage.
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蛋白家族：
Replication factor A protein 2 family
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组织特异性：
Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
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数据库链接：
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