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  4. SLC25A5 Antibody

SLC25A5 Antibody

说明书
  • 中文名称：
    SLC25A5兔多克隆抗体
  • 货号：
    CSB-PA021518LA01HU
  • 规格：
    ￥440
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate
      All lanes: SLC25A5 antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • IHC image of CSB-PA021518LA01HU diluted at 1:700 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC25A5 Polyclonal antibody
  • Uniprot No.：
    P05141
  • 基因名：
    SLC25A5
  • 别名：
    SLC25A5; AAC2; ANT2; ADP/ATP translocase 2; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; Adenine nucleotide translocator 2; ANT 2; Solute carrier family 25 member 5
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ADP/ATP translocase 2 protein (144-175AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC25A5 Antibody (CSB-PA021518LA01HU)，的标记方式是Non-conjugated。对于SLC25A5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021518LB01HU SLC25A5 Antibody, HRP conjugated ELISA
    FITC CSB-PA021518LC01HU SLC25A5 Antibody, FITC conjugated
    Biotin CSB-PA021518LD01HU SLC25A5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SLC25A5 antibodies

SLC25A5 Proteins

靶点详情

  • 功能：
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a...显示更多
  • 基因功能参考文献：
    1. Findings suggest that ANT2 overexpression contributes to EGFR-TKI resistance in non-small cell lung cancer. PMID: 26883272
    2. Study found that ANT2 was upregulated in sorafenibresistant hepatocellular carcinoma Huh7 cell line and its overexpression promoted sorafenib resistance. PMID: 28350139
    3. cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows. PMID: 26842067
    4. ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells. PMID: 27012708
    5. IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2 PMID: 25982278
    6. TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence. PMID: 25220407
    7. Sirt4 regulates ATP levels via ANT2 and a feedback loop involving AMPK. PMID: 24296486
    8. ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression PMID: 23242177
    9. SLC25A5 is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions. PMID: 23783460
    10. miR-636 might function as a tumor suppressor miRNA affecting hepatocellular carcinoma (HCC) tumorigenesis via downregulation of Ras, and that ANT2 suppression by shRNA could exert an anticancer effect by restoring miR-636 expression in HCC. PMID: 23306701
    11. Apigenin upregulates DR5 and enhances TRAIL induced apoptosis by binding and inhibiting ANT2. PMID: 23431365
    12. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
    13. In the context of ovarian cancer, the interaction between CKIepsilon and ANT2 mediates pathogenic signalling that is distinct from the canonical Wnt/beta-catenin pathway and is essential for cell proliferation and is clinically associated with poor survival. PMID: 22707389
    14. ANT2 is not pro-apoptotic and may therefore contribute to carcinogenesis. PMID: 20950584
    15. ANT2 shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 and DR5) and down-regulating the TRAIL decoy receptor 2 (DcR2). PMID: 20875141
    16. ANT2 is able to restore growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC. PMID: 12450408
    17. enhanced binding of NF1 is a key step in the growth arrest repression of ANT2 transcription. PMID: 12777383
    18. expression under hypoxic conditions alters cell cycle in cancer cells PMID: 15486956
    19. Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription. PMID: 18215124
    20. ANT2-specific RNA interference approach to inhibit ANT2 expression resulted in breast cancer cell growth arrest PMID: 18267033

    收起更多

  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 组织特异性：
    Expressed in erythrocytes (at protein level).
  • 数据库链接：

    HGNC: 10991

    OMIM: 300150

    KEGG: hsa:292

    STRING: 9606.ENSP00000360671

    UniGene: Hs.632282

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