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CRTC3 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CRTC3重组抗体
  • 货号：
    CSB-RA955619A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA955619A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CRTC3 Recombinant Monoclonal Antibody（Code: CSB-RA955619A0HU）是一款针对CRTC3蛋白开发的高特异性抗体。CRTC3（CREB-regulated transcription coactivator 3）是调控能量代谢和应激反应的关键分子，通过与CREB等转录因子相互作用参与脂肪代谢、糖异生及细胞分化等重要生物学过程。本抗体通过重组技术制备，经ELISA和免疫组化（IHC）严格验证，在IHC应用中推荐使用1:50-1:200稀释比例，可清晰检测组织样本中CRTC3的定位与表达水平，具有优异的信号特异性和批次稳定性。该产品适用于研究CRTC3在代谢调控、脂肪细胞分化、肝脏功能及相关疾病模型中的作用机制，可为能量代谢通路研究、肥胖或糖尿病等代谢性疾病的基础科研提供可靠工具，支持细胞生物学、分子病理学等领域的实验需求。
  • Uniprot No.：
    Q6UUV7
  • 基因名：
    CRTC3
  • 别名：
    CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3), CRTC3, TORC3
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human CRTC3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    10G3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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CRTC3 antibodies

CRTC3 Proteins

靶点详情

  • 功能：
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia vir...显示更多
  • 基因功能参考文献：
    1. CRTC3-MAML2 gene fusion occurs in hidradenomas. PMID: 29079171
    2. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism PMID: 29979427
    3. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
    4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
    5. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population. PMID: 24264430
    6. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
    7. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
    8. CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone PMID: 21536665
    9. As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans PMID: 21164481
    10. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion. PMID: 19749740
    11. transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR PMID: 15466468
    12. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
    13. BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3 PMID: 17644518
    14. study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. PMID: 18050304

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    TORC family
  • 组织特异性：
    Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
  • 数据库链接：

    HGNC: 26148

    OMIM: 608986

    KEGG: hsa:64784

    STRING: 9606.ENSP00000268184

    UniGene: Hs.567572

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