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  4. DLL3 Recombinant Monoclonal Antibody

DLL3 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    DLL3重组抗体
  • 货号：
    CSB-RA882142A1HU
  • 规格：
    ￥1320
  • 图片：
    • Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2µl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
    • The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
      Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.
    • The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
      Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
    • The purity of DLL3 was greater than 95% as determined by SEC-HPLC
  • 其他：

产品详情

  • 产品描述：
    DLL3重组单克隆抗体（CSB-RA882142A1HU）是针对Delta样配体3（DLL3）靶点开发的高特异性科研用抗体。DLL3作为Notch信号通路的关键调控分子，在细胞分化、组织发育及肿瘤发生中发挥重要作用，尤其在神经内分泌肿瘤和小细胞肺癌等疾病中呈现异常表达特征。本产品采用重组表达技术制备，经ELISA和流式细胞术（FC）严格验证，在FC应用中表现出优异的灵敏度和重复性，推荐使用稀释比例为1:50-1:200，可精准识别天然构象的DLL3蛋白。其均一的单克隆特性确保了实验数据的稳定性和可重复性，适用于细胞表面蛋白定量分析、肿瘤细胞亚群分选、信号通路调控机制研究等领域。科研人员可通过该抗体开展DLL3相关分子机制研究、体外药物靶点筛选及肿瘤标志物检测等实验，为肿瘤生物学研究和抗肿瘤药物开发提供可靠工具。本品严格遵循质量控制标准，适用于体外实验体系，不涉及活体诊断或治疗用途。
  • Uniprot No.：
    Q9NYJ7
  • 基因名：
    DLL3
  • 别名：
    Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3), DLL3
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DLL3 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    7B7
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, FC
  • 推荐稀释比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Flow cytometry (FC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
  • 基因功能参考文献：
    1. these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
    2. Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
    3. our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
    4. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
    5. Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
    6. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
    7. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
    8. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
    9. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
    10. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613

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  • 相关疾病：
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 2909

    OMIM: 277300

    KEGG: hsa:10683

    STRING: 9606.ENSP00000205143

    UniGene: Hs.127792

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